Innate lymphocytes(ILCs)rapidly respond to and protect against invading pathogens and cancer.ILCs include natural killer(NK)cells,ILC1s,ILC2s,ILC3s,and lymphoid tissue inducer(LTi)cells and include type I,type II,and ...
supported by Natural Science Foundation of Shigatse City(No.RKZ2024ZR-002);the National Natural Science Foundation of China(No.32141005);Chongqing Science and Health Joint Medical Research Project(No.2020MSXM127).
The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon(IFN)genes(cGAS-STING)signaling pathway is crucial for sensing abnormal DNA accumulation in the cytoplasm.Once binds to abnor...
Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillan...
supported by the grants from the National Natural Science Foundation of China(No.32170696 to P.Y.);the HRHI Program 202209010 of Westlake Laboratory of Life Sciences and Biomedicine.
Liquid-liquid phase separation(LLPS)has emerged as a crucial mechanism for cellular compartmentalization.One prominent example of this is the stress granule.Found in various types of cells,stress granule is a biomolec...
Over the past few decades,complementary and alternative treatments have become increasingly popular worldwide.The purported therapeutic characteristics of natural products have come under increased scrutiny both in vi...
This work was supported by the Guangdong Basic and Applied Basic Research Foundation(2023A1515011106);General Project of Guangdong Provincial Enterprise Joint Fund(2022A1515220066);Project of Guangzhou Municipal Science and Technology Bureau(2023A04J1825).
Forsythiae Fructus,a well-known traditional Chinese medicine preparation derived from the dried fruits of Forsythia suspensa(Thunb.)Vahl,has been historically utilized for its heat-clearing and detoxification properti...
Supported by National Natural Science Foundation of China(to M.Y.),No.81970468.
The tremendous public health and economic impact of coronavirus disease 2019(COVID-19), caused by severe acute respiratory syndrome coronavirus 2(SARSCoV-2), has become a huge challenge globally. There is increasing e...
Background:Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has caused a global pandemic that has resulted in millions of casualties.Although researchers have reported the existence of neutralizing antibodie...
supported in part by the National Natural Science Foundation of China(31630022,31821003,31991170 and 31600718);Beijing Municipal Science and Technology Commission(Z181100001318007 and Z171100000417005)。
T follicular helper(Tfh)cells are critical in providing help for B cells in the germinal center reaction.Tfh cell plasticity,especially with regard to their expression of effector Th cytokines,has been described,but l...
supported by funding from the National Key R&D Program of China(2021YFC2301900 and 2301904);National Natural Science Foundation of China(81930062);Health Commission of Jilin Province(2020J059);the Key Laboratory of Molecular Virology,Jilin Province(20102209)。
The global spread of enteroviruses(EVs)has become more frequent,severe and life-threatening.Intereron(IFN)I has been proved to control EVs by regulating IFN-stimulated genes(ISG)expression.20-50-oligoadenylate synthet...