Pathogen-associated T follicular helper cell plasticity is critical in anti-viral immunity  

作　　者：Han Feng Xiaohong Zhao Jenny Xie Xue Bai Weiwei Fu Hairong Chen Hong Tang Xiaohu Wang Chen Dong 

机构地区：[1]Institute for Immunology,Tsinghua University,Beijing 100084,China [2]Discovery Immunology,Bristol Myers Squibb,Princeton NJ 08543,USA [3]Department of Gastroenterology,Peking University Third Hospital,Beijing 100191,China [4]CAS Key Laboratory of Infection and Immunity,Institute of Biophysics,Chinese Academy of Science,Beijing 100101,China [5]CAS Key Laboratory of Molecular Virology and Immunology,Institute Pasteur of Shanghai,Chinese Academy of Sciences,Shanghai 200025,China [6]Pasteurien College,Suzhou University,Suzhou 215123,China [7]Shanghai Immune Therapy Institute,Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital,Shanghai 200127,China

出　　处：《Science China(Life Sciences)》2022年第6期1075-1090,共16页中国科学（生命科学英文版）

基　　金：supported in part by the National Natural Science Foundation of China(31630022,31821003,31991170 and 31600718);Beijing Municipal Science and Technology Commission(Z181100001318007 and Z171100000417005)。

摘　　要：T follicular helper(Tfh)cells are critical in providing help for B cells in the germinal center reaction.Tfh cell plasticity,especially with regard to their expression of effector Th cytokines,has been described,but lacks in-depth analysis with genetic approaches.In this study,we systemically compared transcriptomic profiles of Tfh cells derived from various types of immune responses and found gene clusters corresponding to effector Th cells were differentially induced in response to pathogens or immune responses.Of special interest,a subset of Tfh cells producing IFN-γwas generated in an influenza virus infection,partially dependent on the innate cytokine IL-12.Lineage-tracing mouse model revealed unique developmental regulation of IFN-γ~+Tfh cells,while selective ablation of these cells impaired the induction of Ig G2c~+germinal center B cells and the control of influenza infection.These results indicate that pathogen-associated Tfh cell plasticity is necessary for host immunity,which has implications in vaccine design.

关 键 词：T follicular helper(Tfh)cell PLASTICITY influenza infection IFN-γ IgG2 

分 类 号：R392[医药卫生—免疫学]