血流动力学参数在乳腺良恶性病变中的诊断及鉴别诊断的价值  

Hemodynamic parameters in differentiating benign and malignant lesions of the breast

作　　者：刘真真[1] 郭亚飞 陈艳 邢庆娜[1] 陆林[1] LIU Zhen-zhen;GUO Ya-fei;CHEN Yan;XING Qing-na;LU Lin(Department of Radiology,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第三附属医院医学影像科,河南郑州450052

出　　处：《中国临床医学影像杂志》2021年第6期402-404,409,共4页Journal of China Clinic Medical Imaging

基　　金：2021年度河南省重点研发与推广专项(科技攻关)202102310694支持。

摘　　要：目的:探讨基于动态增强磁共振成像(DCE-MRI)技术在诊断及鉴别诊断乳腺良恶性病变中的价值。方法:对53例乳腺病变患者未经治疗时行常规MRI平扫和DCE-MRI成像,其中乳腺良性病变25例,恶性病变28例,测量病变的定量及半定量血流动力学参数K^(trans)、V_(e)、K_(ep)、IAUGC、MaxSlope、CER、PEI,使用校正t检验进行数据统计处理、分析,并运用受试者工作特征曲线(ROC)评价相关血流动力学参数的诊断及鉴别诊断价值。结果:两组病变间K^(trans)、IAUGC、V_(e)、MaxSlope均有统计学意义(P<0.05),其诊断乳腺良恶性病变的ROC曲线下面积分别为0.869、0.825、0.663、0.894,将病理结果作为对照判断乳腺病变良恶性,其敏感度分别为96.2%、92.3%、96.2%、88.5%,特异度分别为66.7%、70.8%、45.5%、79.2%。结论:乳腺良恶性病变的血流动力学特征是不同的,K^(trans)、IAUGC、V_(e)、MaxSlope值对于两者之间的鉴别诊断具有重要的参考价值,可提高诊断正确率。Objective: To explore the dynamic contrast-enhanced(DCE) MRI in the differential diagnoses of benign and malignant lesions of the breast. Methods: Fifty-three patients with breast lesions, which included 25 benign lesions and 28 malignant lesions, underwent conventional MRI and DCE-MRI before therapy. Hemodynamic parameters included K^(trans), V_(e), K_(ep),IAUGC, MaxSlope, CER, PEI were calculated. Receiver operating characteristic(ROC) curves was used to compare diagnostic performance of those parameters. Results: There were important differences of K^(trans), IAUGC, V_(e), MaxSlope(P<0.05). The area under curve of K^(trans), IAUGC, V_(e), MaxSlope was 0.869, 0.825, 0.663, 0.894, respectively. Compared with pathological results,the sensitivity was 96.2%, 92.3%, 96.2%, 88.5% and the specificity was 66.7%, 70.8%, 45.5%, 79.2%, respectively. Conclusion: Different features between benign and malignant lesions of the breast are able to be identified with DCE-MRI. It can be applied as an important tool in the detection of benign and malignant lesions of the breast in order to increase the diagnostic accuracy.

关 键 词：乳腺肿瘤 乳腺疾病 磁共振成像 

分 类 号：R737.9[医药卫生—肿瘤] R655.8[医药卫生—临床医学]