阿司匹林联合神经节苷脂治疗脑梗死的临床疗效分析  

Analysis of clinical efficacy of aspirin combined with ganglioside in the treatment of cerebral infarction

作　　者：李泳祺 LI Yong-qi(Third Affiliated Hospital of Guangdong Medical University(Longjiang Hospital of Shunde District)Foshan 528318,China)

机构地区：[1]广东医科大学附属第三医院(佛山市顺德区龙江医院),528318

出　　处：《中国实用医药》2021年第18期96-98,共3页China Practical Medicine

摘　　要：目的分析阿司匹林联合神经节苷脂治疗脑梗死的临床疗效。方法50例脑梗死患者,依据随机数字表法分为对照组与观察组,每组25例。对照组患者给予阿司匹林治疗,观察组患者在对照组治疗基础上增加神经节苷脂治疗。比较两组住院时间,治疗前后日常生活活动能力及神经功能缺损程度、血清学炎症因子[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)和白细胞介素-6(IL-6)]水平,临床疗效及不良反应发生情况。结果观察组住院时间为(12.51±2.26)d,短于对照组的(16.56±3.28)d,差异具有统计学意义(P<0.05)。治疗后,两组BI指数、美国国立卫生研究院卒中量表(NIHSS)评分及TNF-α、hs-CRP、IL-6水平均优于本组治疗前,且观察组BI指数、NIHSS评分、TNF-α、hs-CRP、IL-6水平分别为(84.51±3.21)分、(10.53±1.02)分、(1.52±0.21)ng/ml、(7.15±1.02)mg/L、(61.28±2.16)pg/ml,均优于对照组的(76.56±3.25)分、(16.21±1.45)分、(2.41±0.28)ng/ml、(9.22±1.52)mg/L、(121.67±2.78)pg/ml,差异均具有统计学意义(P<0.05)。观察组治疗总有效率为96.00%,显著高于对照组的76.00%,差异具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论阿司匹林联合神经节苷脂对于脑梗死的治疗效果确切,可有效减轻患者的神经功能缺损程度,提高患者的生活自理能力,并有利于控制机体炎症,值得推广和应用。Objective To analyze the clinical efficacy of aspirin combined with ganglioside in the treatment of cerebral infarction.Methods A total of 50 patients with cerebral infarction were divided into control group and observation group according to random numerical table,with 25 cases in each group.The control group was treated with aspirin,and the observation group was treated with ganglioside based on the control group.The hospitalization time,activities of daily living and neurological deficit,serum inflammatory factors[tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)]before and after treatment,clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results The hospitalization time(12.51±2.26)d of the observation group was shorter than(16.56±3.28)d of the control group,and the difference was statistically significant(P<0.05).After treatment,the Barthel index(BI)score,National Institutes of Health stroke scale(NIHSS)score,TNF-α,hs-CRP and IL-6 of the two groups were better than those before treatment,and the BI score(84.51±3.21)points,NIHSS score(10.53±1.02)points,TNF-α(1.52±0.21)ng/ml,hs-CRP(7.15±1.02)mg/L and IL-6(61.28±2.16)pg/ml of the observation group were better than(76.56±3.25)points,(16.21±1.45)points,(2.41±0.28)ng/ml,(9.22±1.52)mg/L and(121.67±2.78)pg/ml of the control group.All the difference was statistically significant(P<0.05).The total effective rate 96.00%of the observation group was significantly higher than 76.00%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion Combination of aspirin and ganglioside has affirmative effect on cerebral infarction,which can effectively reduce the degree of neurological deficit,improve the activities of daily living,and help to control the body inflammation.It is worthy of promotion and application.

关 键 词：脑梗死 阿司匹林 神经节苷脂 日常生活活动能力 神经功能缺损程度 血清学炎症因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]