奥曲肽结合泮托拉唑对肝炎后肝硬化并食管胃底静脉曲张破裂出血的治疗效果及止血情况分析  

Therapeutic effect of octreotide combined with pantoprazole in the treatment of post-hepatitis liver cirrhosis and bleeding from esophageal and gastric varices and analysis of hemostasis

作　　者：陈聪 黄建鑫 罗玉娟 李明[1] CHEN Cong;HUANG Jian-xin;LUO Yu-juan(Department of Gastroenterology,Zhaoqing First People’s Hospital,Zhaoqing 526020,China)

机构地区：[1]肇庆市第一人民医院消化内科,526020 [2]肇庆市第一人民医院体检中心,526020

出　　处：《中国实用医药》2021年第18期109-112,共4页China Practical Medicine

摘　　要：目的探究奥曲肽结合泮托拉唑对肝炎后肝硬化并食管胃底静脉曲张破裂出血的治疗效果及止血情况。方法90例肝炎后肝硬化并食管胃底静脉曲张破裂出血患者,按照治疗方法不同分为对照组与治疗组,每组45例。对照组单一使用奥曲肽治疗,治疗组采用奥曲肽结合泮托拉唑治疗。比较两组患者的治疗效果、止血情况(止血有效率、止血时间、再出血率、血红蛋白水平)、不良反应发生率及治疗前后的血压水平。结果治疗组患者的总有效率91.11%高于对照组的75.56%,差异具有统计学意义(P<0.05)。治疗组患者的止血有效率、血红蛋白水平高于对照组,止血时间短于对照组,再出血率低于对照组,差异具有统计学意义(P<0.05)。治疗组患者的不良反应发生率8.89%低于对照组31.11%,差异具有统计学意义(P<0.05)。治疗后,治疗组患者的收缩压(102.79±11.72)mm Hg(1 mm Hg=0.133 kPa)、舒张压(82.12±9.36)mm Hg高于对照组的(94.23±10.39)、(68.43±9.78)mm Hg,差异具有统计学意义(P<0.05)。结论奥曲肽结合泮托拉唑对肝炎后肝硬化并食管胃底静脉曲张破裂出血有较为显著的治疗效果,不良反应发生率低,可以有效缩短止血时间,值得临床推广应用。Objective To investigate the therapeutic effect of octreotide combined with pantoprazole in the treatment of post-hepatitis liver cirrhosis and bleeding from esophageal and gastric varices and analysis of hemostasis.Methods A total of 90 patients with post-hepatitis liver cirrhosis and bleeding from esophageal and gastric varices were divided into control group and treatment group according to different treatment methods,with 45 cases in each group.The control group was treated with octreotide,and the treatment group was treated with octreotide and pantoprazole.The therapeutic effect,hemostasis(effectiveness of hemostasis,hemostasis time,rebleeding rate,hemoglobin level),occurrence of adverse reactions,and blood pressure before and after treatment were compared between the two groups.Results The total effective rate 91.11%of the treatment group was higher than 75.56%of the control group,and the difference was statistically significant(P<0.05).The effectiveness rate of hemostasis and hemoglobin level of the treatment group were higher than those of the control group,hemostasis time was shorter than that of the control group,and rebleeding rate was lower than that of the control group.All the difference was statistically significant(P<0.05).The incidence of adverse reactions 8.89%of the treatment group was lower than 31.11%of the control group,and the difference was statistically significant(P<0.05).After treatment,the systolic blood pressure(102.79±11.72)mm Hg(1 mm Hg=0.133 kPa)and diastolic blood pressure(82.12±9.36)mm Hg of the treatment group were higher than(94.23±10.39)and(68.43±9.78)mm Hg of the control group,and the difference was statistically significant(P<0.05).Conclusion Combination of octreotide and pantoprazole has remarkable effect on the treatment of post-hepatitis liver cirrhosis and bleeding from esophageal and gastric varices,and it has low incidence of adverse reactions and can effectively shorten the hemostasis time,which is worthy of clinical promotion and application.

关 键 词：奥曲肽 泮托拉唑 肝炎 肝硬化 食管胃底静脉曲张破裂出血 止血情况 

分 类 号：R575.2[医药卫生—消化系统] R575.1[医药卫生—内科学]