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作 者:Chen-Yu Ding Fang-Yu Wang Han-Pei Cai Xiao-Yong Chen Shu-Fa Zheng Liang-Hong Yu Yuan-Xiang Lin Zhang-Ya Lin De-Zhi Kang
出 处:《Chinese Neurosurgical Journal》2020年第4期196-203,共8页中华神经外科杂志(英文)
基 金:supported by grants from the key clinical specialty discipline construction program of Fujian,P.R.C.;the major project of Fujian Provincial Department of Science and Technology(no.2014YZ0003),The funding body played an important role in the design of the study.
摘 要:Background:Inflammation has been believed to be related to the development of cerebral vasospasm following aneurysmal subarachnoid hemorrhage(aSAH).A potential biomarker for vascular inflammation that is well recognized is the lipoprotein-associated phospholipase A2(Lp-PLA2).However,whether Lp-PLA2 can predict the occurrence of symptomatic cerebral vasospasm(SCV)in aSAH patients is still unknown.Thus,this study aimed to assess the value of Lp-PLA2 for predicting SCV in patients with aSAH.Methods:Between March 2017 and April 2018,we evaluated 128 consecutive aSAH patients who were admitted in the First Affiliated Hospital of Fujian Medical University.Their Lp-PLA2 level was obtained within 24 h of the initial bleeding.Factors might be related to SCV were analyzed.Results:Compared to patients without SCV,those with SCV(9.4%,12/128)had significantly higher Lp-PLA2 level.Multivariate logistic analysis revealed that worse modified Fisher grade(OR=10.08,95%CI=2.04–49.86,P=0.005)and higher Lp-PLA2 level(OR=6.66,95%CI=1.33–3.30,P=0.021)were significantly associated with SCV,even after adjustment for confounders.Based on the best threshold,Lp-PLA2 had a sensitivity of 83.3%and a specificity of 51.7%for predicting SCV,as shown by the receiver operating characteristic curve analysis.In the poor World Federation of Neurosurgical Societies grade patient sub-group,patients with Lp-PLA2>200μg/L had significantly higher SCV rate than that of patients having Lp-PLA2≤200μg/L.Conclusion:The admission Lp-PLA2 level might be a helpful predictor for SCV in aSAH.
关 键 词:Aneurysmal subarachnoid hemorrhage VASOSPASM Biological markers
分 类 号:R743.35[医药卫生—神经病学与精神病学]
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