MicroRNAs调控结直肠癌干细胞的研究进展  

Research progress of micro RNAs regulating colorectal cancer stem cells

作　　者：欧苏文 罗康佳 管子龙 黄睿[1] Ou Suwen;Luo Kangjia;Guan Zilong;Huang Rui(Department of Colorectal Surgery,the Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属第二医院结直肠肿瘤外科,150081

出　　处：《中华结直肠疾病电子杂志》2021年第3期306-312,共7页Chinese Journal of Colorectal Diseases(Electronic Edition)

基　　金：国家自然科学基金面上项目(No.81872034);黑龙江省自然科学基金面上项目(No.H2017016);吴阶平医学基金会(No.320.6750.19092-41);湖北陈孝平科技发展基金会(No.CXPJJH12000002-2020025)。

摘　　要：结直肠癌干细胞(CCSCs)是结直肠癌组织中具有自我更新和增殖分化潜能的一个亚群,它能够启始和驱动结直肠癌的发生、进展,并且与结直肠癌的复发、转移、放化疗抵抗等生物学行为密切相关。MicroRNAs是一类参与转录后调控的小分子非编码RNA。已有大量的研究表明MicroRNAs在CCSCs自我更新、增殖、分化、耐药等多种生物学过程中发挥着重要的调控作用。本文概述了MicroRNAs调控CCSCs特性的各种机制,尤其是作用于多种信号通路,以及MicroRNAs在结直肠癌诊治中的应用前景。深入研究MicroRNAs在CCSCs中的分子机制,有助于更好理解结直肠癌干细胞的生物学特征,并为靶向肿瘤干细胞的结直肠癌临床治疗提供新的参考。Colorectal cancer stem cells(CCSCs)are a subpopulation of colorectal cancer cells with the potential of self-renewal,proliferation and differentiation,which can initiate and promote the occurrence and progress of colorectal cancer.And it is closely related to the recurrence,metastasis,radiotherapy and chemotherapy resistance of colorectal cancer.MicroRNAs are a kind of small noncoding RNAs,involved in post-transcriptional regulation.A large number of studies have shown that MicroRNAs play an important role in the self-renewal,proliferation,differentiation,drug resistance and other biological processes of colorectal cancer stem cells.Herein we summarized various mechanisms of MicroRNAs regulating the characteristics of colorectal cancer stem cells,especially in a variety of signal pathways.In addition,we introduced the application prospect of MicroRNAs in the diagnosis and treatment of colorectal cancer.Advanced study of the molecular mechanism of MicroRNAs in colorectal cancer stem cells will help us to understand the biological characteristics and behavior of colorectal cancer stem cells better,and will also provide a new reference for clinical treatment of targeted colorectal cancer stem cells.

关 键 词：结直肠肿瘤 MICRORNAS 肿瘤干细胞 

分 类 号：R735.34[医药卫生—肿瘤]