快速镇痛方案用于中重度癌痛患者的临床效果  

Clinical effect of rapid analgesia scheme for patients with moderate to severe cancer pain

作　　者：吴红 管林[1] 高勇[1] 崔健 侯军君 崔月倩 张平[2] WU Hong;GUAN Lin;GAO Yong;CUI Jian;HOU Junjun;CUI Yueqian;ZHANG Ping(Taian Cancer Prevention and Treatment Hospital,Taian 271000;Taian City Central Hospital Branch,Taian 271000,China)

机构地区：[1]山东省泰安市肿瘤防治院,山东泰安271000 [2]山东省泰安市中心医院分院,山东泰安271000

出　　处：《临床医学研究与实践》2021年第19期65-67,共3页Clinical Research and Practice

基　　金：泰安市科学技术发展计划项目(No.2019NS218)。

摘　　要：目的比较和分析吗啡快速镇痛方案和口服无背景滴定方案对中重度癌痛患者的镇痛效果。方法选取我院2018年1月至2019年6月收治的60例中重度癌痛患者为研究对象,将其随机分为口服无背景滴定组(口服组)和快速镇痛组(快速组),每组30例。比较两组的NRS评分、滴定所需时间、疼痛缓解程度、KPS评分及不良反应发生情况。结果两组滴定后的NRS评分显著低于滴定前(P<0.05)。快速组的滴定所需时间显著短于口服组(P<0.05)。滴定完成时,两组患者疼痛均明显缓解,疼痛平均缓解程度>65%。滴定后,两组的KPS评分均明显高于滴定前(P<0.05)。两组的各项不良反应发生率比较,差异无统计学意义(P>0.05)。结论以吗啡为背景滴定治疗中重度癌痛时,快速镇痛方案较口服无背景滴定方案更能在较短时间内完成,两者不良反应相当。Objective To compare and analyze the analgesic effects of morphine rapid analgesia scheme and oral background-free titration schemes in patients with moderate to severe cancer pain.Methods Sixty patients with moderate to severe cancer pain treated in our hospital from January 2018 to June 2019 were selected as the study objects and randomly divided into oral background-free titration group(oral group)and rapid analgesia group(rapid group),with 30 cases in each group.NRS score,titration time,pain relief degree,KPS score and adverse reactions were compared between the two groups.Results The NRS scores of the two groups after titration were significantly lower than those before titration(P<0.05).The titration time of the rapid group was significantly shorter than that of the oral group(P<0.05).At the end of titration,the pain of the two groups significantly relieved,and the average degree of pain relief were more than 65%.After titration,the KPS scores of the two groups were significantly higher than those before titration(P<0.05).There were no significant difference in the incidences of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of moderate to severe cancer pain with morphine as background titration,the rapid analgesia scheme can be completed in shorter time than the oral background-free titration scheme,and the adverse reactions of the two schemes are similar.

关 键 词：快速镇痛方案 癌痛 吗啡缓释片 吗啡注射液 

分 类 号：R730.5[医药卫生—肿瘤]