气相色谱法测定左氧氟沙星中N-甲基哌嗪的含量  

Determination of N-Methyl Piperazine in Levofloxacin by GC

作　　者：黄萍 梁越彬 丁婷婷[1] 王莉 陈健 白妍 高浩凌 HUANG Ping;LIANG Yue-bin;DING Ting-ting;WANG Li;CHEN Jian;BAI Yon;GAO Hao-ling(Zhejiang Medicine Co.,Ltd,Xinchang Pharmaceutical Factory,Shaoxing 312500,China;Changhai Biological Compamy,Zhejiang Medicine Co.,Ltd.,Shaoxing 312300,China)

机构地区：[1]浙江医药股份有限公司新昌制药厂,浙江绍兴312500 [2]浙江医药股份有限公司昌海生物分公司,浙江绍兴312300

出　　处：《精细化工中间体》2021年第2期66-68,共3页Fine Chemical Intermediates

摘　　要：采用气相色谱直接进样法测定左氧氟沙星中N-甲基哌嗪的含量,考察了专属性、检测限和定量限、精密度、回收率、线性和范围、耐用性。结果表明建立的方法可用于左氧氟沙星中N-甲基哌嗪质量控制。Determination of N-methylpiperazine in levofloxacin by gas chromatography was achieved. The specificity, limit of detection and quantification, precision, recovery, linearity and range, durability were investigated.The established analytical method could be used for the quality control of N-methyl piperazine in Levofloxacin.

关 键 词：气相色谱法 左氧氟沙星 N-甲基哌嗪 残留溶剂 

分 类 号：O657.71[理学—分析化学]