加替沙星环合酯的波谱数据和结构确证  

Spectral Analysis and Structural Identification of Gatifloxacin Macrolide

作　　者：银瑞峰 何益民 王智慧 王莉 吴孔涛 曹静 高浩凌 YIN Rui-feng;HE Yi-ming;WANG Zhi-hui;WANG Li;WU Kong-tao;CAO Jing;GAO Hao-ling(Zhejiang Medicine Co.,Ltd.,Xinchang Pharmaceutical Factory,Shaoxing 312500,China;Zhejiang Novus Pharmaceuticals Co.,Ltd.,Shaoxiang 312300,China;Changhai Biological Compamy,Zhejiang Medicine Co.,Ltd.,Shaoxing 312300,China)

机构地区：[1]浙江医药股份有限公司新昌制药厂,浙江绍兴312500 [2]浙江创新生物有限公司,浙江绍兴312300 [3]浙江医药股份有限公司昌海生物分公司,浙江绍兴312300

出　　处：《精细化工中间体》2021年第2期69-72,共4页Fine Chemical Intermediates

摘　　要：通过UV、 IR、 HRMS、 NMR (1H NMR、13C NMR、 DEPT135、1H-1H COSY、 HMQC、 HMBC、D2O)数据对合成加替沙星、巴洛沙星和莫西沙星的关键中间体加替沙星环进行结构表征,并对其核磁共振波谱进行了详细的解析和归属。综合运用多种谱学方法确证了其的结构,为其质量研究提供参考。Gatifloxacin macrolide is a key intermediate in the synthesis of Gatifloxacin,Balofloxacin and Moxifloxacin.In this paper,A variety of spectroscopic methods including UV,IR,HRMS,NMR (1H NMR,13C NMR,DEPT135,1H-1H COSY,HMQC,HMBC,D2O) were used to characterize the structure of Gatifloxacin macrolide,and data were analyzed in detail to provide a reference for its quality research.

关 键 词：氟喹诺酮抗生素 波谱表征 结构确证 

分 类 号：O657[理学—分析化学]