2019年泰州市某医院宫颈鳞状上皮内病变和鳞状细胞癌患者人乳头瘤病毒感染特征  

Human papillomavirus infections among patients with cervical squamous intraepithelial lesions and squamous cell carcinoma in a hospital of Taizhou city in 2019

作　　者：杨旭梅 张文妍 金蓉蓉 朱晓蔚[2] 陈民[2] 于鸿[2] Yang Xumei;Zhang Wenyan;Jin Rongrong;Zhu Xiaowei;Chen Min;Yu Hong(Dalian Medical University,Dalian 116044,Liaoning,China;Taizhou People’s Hospital,Taizhou 225300,Jiangsu,China)

机构地区：[1]大连医科大学,辽宁大连116044 [2]泰州市人民医院,江苏泰州225300

出　　处：《中国疫苗和免疫》2021年第3期280-284,共5页Chinese Journal of Vaccines and Immunization

基　　金：泰州市人民医院院级科研基金(ZL201815)。

摘　　要：目的探讨宫颈低度鳞状上皮内病变(LSIL)、高度鳞状上皮内病变(HSIL)和鳞状细胞癌(SCC)患者人乳头瘤病毒(Human papillomavirus,HPV)基因型分布特征。方法选择2019年泰州市人民医院经病理学确诊的LSIL、HSIL和SCC患者,采集宫颈组织标本,采用PCR-反向点杂交法检测23种HPV基因型,分析HPV感染率。结果调查对象HPV总感染率为83.83%(788/940),其中LSIL、HSIL、SCC患者分别为80.57%(394/489)、85.11%(303/356)、95.79%(91/95)。在高危型HPV中HPV16、52、58、33、18感染率分别为35.64%、16.91%、13.94%、8.94%、7.98%;在低危型HPV中HPV81、6、43、42感染率分别为4.47%、2.87%、2.87%、2.02%。40-44岁和55-59岁年龄组HPV感染率最高,分别为87.94%和89.80%。结论宫颈病变患者的HPV感染率较高,以HPV16、52、58、33和18基因型为主;宫颈病变患者HPV感染率呈40-44岁和55-59岁两个年龄高峰。建议加强适龄女性宫颈癌筛查和HPV疫苗接种。Objective To explore the distribution of human papillomavirus(HPV)genotypes in patients with low-grade cervical squamous intraepithelial lesions(LSIL),high-grade squamous intraepithelial lesion(HSIL),and squamous cell carcinoma(SCC).Methods We selected patients who were histologically confirmed to have LSIL,HSIL,or SCC in Taizhou People’s Hospital in 2019.We collected cervical specimens and detected 23 HPV genotypes using PCR-reverse dot blot for an analysis of HPV infection rates.Results Among all subjects,the HPV infection rate was 83.83%(788/940),with rates of 80.57%(394/489),85.11%(303/356),and 95.79%(91/95)among LSIL,HSIL,and SCC patients,respectively.Infection rates of high-risk HPVs genotypes 16,52,58,33,and 18 were 35.64%,16.91%,13.94%,8.94%,and 7.98%.Infection rates of low-risk HPV types 81,6,43,and 42 were 4.47%,2.87%,2.87%,and 2.02%.The highest HPV infection rates were among 40-44-and 55-59-year-olds at 87.94%and 89.80%,respectively.Conclusions Patients with cervical lesions had high levels of HPV infection,with predominant HPV genotypes being 16,52,58,33,and 18.The highest prevalence was among 40-44-and 55-59-year-olds.We suggest cervical cancer screening and HPV vaccination for age-eligible women.

关 键 词：人乳头瘤病毒 基因型 宫颈鳞状上皮内病变 宫颈鳞状细胞癌 

分 类 号：R737.33[医药卫生—肿瘤] R711.32[医药卫生—临床医学]