盐酸文拉法辛缓释片治疗抑郁焦虑共病的疗效观察  

Curative Effect Observation of Venlafaxine Hydrochloride Sustained-release Tablets in Treating Comorbid Depression and Anxiety

作　　者：赵晓曼 ZHAO Xiaoman(The First Mental Ward,Shenyang Mental Health Center,Shenyang 110168,China)

机构地区：[1]沈阳市精神卫生中心心理一病房,辽宁沈阳110168

出　　处：《中国医药指南》2021年第15期69-70,共2页Guide of China Medicine

摘　　要：目的探讨盐酸文拉法辛缓释片治疗抑郁焦虑共病的疗效。方法将我院2016年4月至2018年12月收治的80例抑郁焦虑共病患者,随机分组。给予帕罗西汀治疗干预组帕罗西汀治疗,盐酸文拉法辛缓释片治疗组则开展盐酸文拉法辛缓释片治疗。比较两组抑郁焦虑共病治疗效果;药物起效时间、住院时间;治疗前后汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分;药物不良反应发生率。结果盐酸文拉法辛缓释片治疗组抑郁焦虑共病治疗效果高于帕罗西汀治疗干预组,P<0.05。盐酸文拉法辛缓释片治疗组治疗后HAMA评分、HAMD评分显著低于帕罗西汀治疗干预组,P<0.05。盐酸文拉法辛缓释片治疗组药物起效时间、住院时间短于帕罗西汀治疗干预组,P<0.05。盐酸文拉法辛缓释片治疗组药物不良反应发生率低于帕罗西汀治疗干预组,P<0.05。结论抑郁焦虑共病患者实施盐酸文拉法辛缓释片治疗的效果确切,可有效改善患者的焦虑和抑郁程度,且起效更快,不良反应少,安全性高。Objective To investigate the efficacy of venlafaxine hydrochloride sustained-release tablets in the treatment of comorbid depression and anxiety.Methods Eighty patients with comorbid depression and anxiety who were admitted to our hospital from April 2016 to December 2018 were randomly divided into groups.The paroxetine treatment intervention group was given paroxetine treatment,and the venlafaxine hydrochloride sustained-release tablets treatment group was given venlafaxine hydrochloride sustained-release tablets treatment.The treatment effects of comorbid depression and anxiety were compared between the two groups;drug onset time and hospital stay;Hamilton Anxiety Scale(HAMA)scores and Hamilton Depression Scale(HAMD)scores before and after treatment;incidence of adverse drug reactions.Results The treatment effect of venlafaxine hydrochloride sustained-release tablets for depression and anxiety comorbidities was higher than that of paroxetine treatment intervention group,P<0.05.The HAMA score and HAMD score of the venlafaxine hydrochloride sustained-release tablet treatment group were significantly lower than those in the paroxetine treatment intervention group after treatment,P<0.05.Venlafaxine hydrochloride sustained-release tablets treatment group has shorter drug onset time and hospital stay than paroxetine treatment intervention group,P<0.05.The incidence of adverse drug reactions in the treatment group of venlafaxine hydrochloride sustained-release tablets was lower than that in the paroxetine treatment intervention group,P<0.05.Conclusion The effect of venlafaxine hydrochloride sustained-release tablets for patients with depression and anxiety comorbidities is definite,which can effectively improve the anxiety and depression of patients,with faster onset,fewer adverse reactions and high safety.

关 键 词：盐酸文拉法辛缓释片 抑郁焦虑共病 疗效 

分 类 号：R749.3[医药卫生—神经病学与精神病学]