心肺复苏后全脑缺血再灌注损伤的研究进展  

Progress of global cerebral ischemia reperfusion injury after cardiopulmonary resuscitation

作　　者：康晓宇 刘丽旭[1] Kang Xiaoyu;Liu Lixu(Department of Neurological Rehabilitation I,School of Rehabilitation Medicine,Capital Medical University,Beijing Bo’ai Hospital,China Rehabilitation Research Centre,Beijing 100068,China)

机构地区：[1]首都医科大学康复医学院·中国康复研究中心北京博爱医院神经康复一科,北京100068

出　　处：《中华脑科疾病与康复杂志（电子版）》2021年第2期116-120,共5页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

基　　金：中国康复研究中心科研项目(2017ZX-11)。

摘　　要：心肺复苏后的脑功能障碍是影响患者病死率和致残率的主要因素,然而迄今为止针对心肺复苏后全脑缺血再灌注损伤患者的治疗手段仍非常有限,如何针对心脏骤停后全脑缺血再灌注损伤进行有效的脑保护,也是目前亟待解决的一大难题。因此,本文针对心肺复苏后全脑缺血再灌注损伤的概念、流行病学、病理生理机制及治疗手段的研究进展作一综述。Brain dysfunction after cardiopulmonary resuscitation is the main factor affecting the mortality and morbidity of patients.However,the treatment of global cerebral ischemia-reperfusion injury after cardiopulmonary resuscitation is still very limited.How to effectively protect the brain after global cerebral ischemia-reperfusion injury caused by cardiac arrest is a big problem to be solved urgently.This review is based on the concept,epidemiology,pathophysiological mechanisms and therapies of global cerebral ischemia reperfusion injury after cardiopulmonary resuscitation in order to introduce its research progress.

关 键 词：心肺复苏 心脏骤停 脑缺血再灌注损伤 药物治疗 脑保护 

分 类 号：R541.78[医药卫生—心血管疾病] R743[医药卫生—内科学]