血清miR⁃146a、miR⁃195水平与糖尿病视网膜病变患者激光治疗效果的相关性  

Correlation between serum miR⁃146a,miR⁃195 levels and effect of laser treatment in patients with diabetic retinopathy

作　　者：徐家窈[1] 郑海生[1] 陈海燕 冼文光[2] XU Jiayao;ZHENG Haisheng;CHEN Haiyan;XIAN Wenguang(Department of Corneal Diseases,Hainan Eye Hospital,Zhongshan Ophthalmic Center of Sun Yat-sen University(Hainan Eye Hospital),Haikou 571300,China;不详)

机构地区：[1]中山大学中山眼科中心海南眼科医院(海南省眼科医院)角膜病科,海口571300 [2]中山大学中山眼科中心海南眼科医院海南省眼科医院眼底病科,海口571300

出　　处：《实用医学杂志》2021年第12期1554-1558,共5页The Journal of Practical Medicine

基　　金：海南省自然科学基金面上项目(编号:819MS133)。

摘　　要：目的观察糖尿病视网膜病变(DR)患者血清微小RNA⁃146a(miR⁃146a)、miR⁃195水平与激光治疗效果的相关性。方法选择我院2018年1月至2020年1月收治的111例DR患者作为研究对象,检测患者血清miR⁃146a、miR⁃195水平,行激光治疗,评估激光治疗效果,分析血清miR⁃146a、miR⁃195水平与DR患者激光治疗效果的相关性。结果223例DR患者行激光治疗后,有181例治疗有效,有42例治疗无效;初步比较激光治疗无效组与治疗有效组资料后,经logistic回归分析结果显示,DR患者高血压、治疗前血清miR⁃146a及miR⁃195水平是激光治疗无效的影响因素(OR>1,P<0.05);绘制受试者工作曲线(ROC)发现,治疗前血清miR⁃146a及miR⁃195水平单项预测及联合预测激光治疗无效的曲线下面积(AUC)均>0.80,有一定预测性能。结论血清miR⁃146a、miR⁃195可作为DR患者激光治疗效果的有效预测指标。Objective To observe the correlation between serum microRNA⁃146a(miR⁃146a)and miR⁃195 levels and the effect of laser treatment in patients with diabetic retinopathy(DR).Methods 111 patients with DR admitted to our hospital from January 2018 to January 2020 were selected as the research subjects.The serum levels of miR⁃146a and miR⁃195 were detected before treatment,and laser treatment was performed.Evaluated the effect of laser treatment,analyzed the correlation between serum miR⁃146a and miR⁃195 levels and the effect of laser treatment in DR patients.Results Among 223 DR patients after laser treatment,181 cases were effective and 42 cases were ineffective;after preliminary comparing the data of the ineffective group and the effective group by Logistic regression analysis,the results showed that hypertension,pre⁃treatment serum miR⁃146a and miR⁃195 levels in DR patients were the influencing factors of laser treatment ineffectiveness(OR>1,P<0.05);the receiver operating characteristic curve(ROC)was drawn and found that the pre⁃treatment serum miR⁃146a and miR⁃195 levels single predicted and combined predicted area under the curve(AUC)of laser treatment failure were both>0.80,with certain predictive performance.Conclusion Serum miR⁃146a and miR⁃195 can be used as predictive indexes of ineffective laser treatment in DR patients.

关 键 词：糖尿病视网膜病变 微小RNA⁃146a 微小RNA⁃195 激光 血糖 高血压 

分 类 号：R779.63[医药卫生—眼科] R587.2[医药卫生—临床医学]