Gastrointestinal bleeding during acute ischaemic stroke hospitalisation increases the risk of stroke recurrence  

作　　者：Wanliang Du Xingquan Zhao Yilong Wang Yuesong Pan Gaifen Liu Anxin Wang Ruijun Ji Liping Liu Hongqiu Gu Kehui Dong Penglian Wang Yongjun Wang 

机构地区：[1]Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing,China [2]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease,Beiing,China [3]Center of Stroke,Beijing Institute for Brain Disorders,Beijing,China [4]China National Clinical Research Center for Neurological Diseases,Beijing,China [5]Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing,China

出　　处：《Stroke & Vascular Neurology》2020年第2期116-120,共5页卒中与血管神经病学（英文）

基　　金：supported by grants from the National Key Research and Development Program from the Ministry of Science and Technology of China(2018YFC1312400);the Ministry of Science and Technology of the People’s Republic of China(2016YFC0901002,2016YFC0901001,2017YFC1310901,2017YFC1307905 and 2018YFC1312903);grants from Beijing Municipal Administration of Hospitals’Mission Plan(SML20150502);grants from National Natural Science Foundation of China(81600999);grants from Beijing Municipal Science&Technology Commission(D171100003017002 and D151100002015003);grants from National Science and Technology Major Project(2017ZX09304018).

摘　　要：Objective Gastrointestinal(GI)bleeding in patients who had a stroke is strongly associated with a higher risk of death and loss of independence.However,it is unknown whether GI bleeding increases risk for recurrence of stroke.In this study,we assess the potential relationship between GI bleeding and stroke recurrence in patients within 12 months of an acute ischaemic stroke(AIS),using the China National Stroke Registry(CNSR).Methods This study included 22216 patients who had an ischaemic stroke included in the CNSR from 2007 to 2008.We analysed baseline patient characteristics,GI bleeding and outcomes of patients who had an AIS,specifically stroke recurrence at 3,6 and 12 months.We used multivariable logistic regression to evaluate a possible association between GI bleeding and stroke recurrence.results Of the 12415 patients included in our study,12.3%,15.5%and 17.7%had a stroke recurrence at 3,6 and 12 months,respectively.GI bleeding was an independent stroke recurrence risk factor in patients after ischaemic stroke at 3 months(adjusted OR 1.481,95%CI 1.118 to 1.962),6 months(adjusted OR 1.448,95%CI 1.106 to 1.896)and 12 months(adjusted OR 1.350;95%CI 1.034 to 1.763).Conclusion GI bleeding was associated with the increased risk of stroke recurrence after an AIS.

关 键 词：BLEEDING GASTROINTESTINAL ACUTE 

分 类 号：R743.3[医药卫生—神经病学与精神病学]