原发性慢性青光眼患者双眼视觉和生活质量相关性研究  

Correlation between the binocular visual field and visual function quality of life in patients with primary chronic glaucoma

作　　者：秦小美 梁远波[3,4] 原慧萍[1] QIN Xiaomei;LIANG Yuanbo;YUAN Huiping(Department of Ophthalmology,The Second Affiliated Hospital of Harbin Medical University,Harbin 150086;Department of Ophthalmology,the Third People's Hospital of Huizhou City,Huizhou Guangdong 516002;Department of Ophthalmology,Beijing Tongren Hospital,Beijing 100730;Department of Ophthalmology,Affiliated Optometry Hospital,Wenzhou Medical College,Wenzhou Zhejiang 32500,China)

机构地区：[1]哈尔滨医科大学附属第二医院眼科,哈尔滨150086 [2]广东省惠州市第三人民医院眼科,广东惠州516002 [3]北京同仁医院眼科,北京100730 [4]温州医学院附属眼视光医院眼科,浙江温州325000

出　　处：《眼科学报》2021年第6期465-472,共8页Eye Science

摘　　要：目的:评估与原发性慢性青光眼患者生活质量最具相关性的视觉指标。方法:回顾性病例系列研究。收集2010年3月至2010年8月就诊于首都医科大学附属北京同仁医院且符合入选及排除标准的原发性慢性闭角型青光眼和原发性开角型青光眼患者131例262只眼。采用Humphrey Field Analyzer II 750i型视野分析仪对入选患者分别进行单眼Cent ral 24-2程序和Esterman双眼视野检查程序(Esterman Binocular Visual Field Test,EBVFT)各两次检查,以保证所得数据的可靠性。使用LogMAR视力表检查并记录受试者日常单眼生活视力和日常双眼生活视力、非接触式眼压计测量眼压、直接眼底镜检查视神经的杯盘比。记录病史及目前所使用抗青光眼药物,角膜及晶状体状态。应用视功能相关生活质量量表-25(25-Item National Eye Institute Visual Function Questionnaire,VFQ-25)对患者进行生活质量评估,并将双眼日常生活视力、较好眼生活视力、较差眼视野MD(mean defect)值、较好眼视野MD值、(Esterman Visual Field Test,EVFT)效用值和VFQ-25得分进行相关性分析。结果:共有131例受试者符合入选条件。在患者生存质量的统计中,自我评价视力、近距离活动、远距离活动、社会功能、依赖程度、色觉、视野这7项得分较好,即受试者完成该7项的能力较高。VFQ-25总分与EBVFT效用值成正相关(r=0.24998,P=0.004<0.05),与双眼日常生活视力成负相关(r=−0.37778,P<0.0001),与较差眼视野MD值成正相关(r=0.22917,P=0.0187<0.05),与较好眼生活视力、较好眼视野、较差眼生活视力无明显相关关系。结论:原发性慢性青光眼患者双眼视觉(双眼视野和双眼日常生活视力)和VFQ-25有良好的相关性,可用于评估慢性青光眼患者的生活质量。Objective:To assess the correlation between the Esterman binocular visual field(EBVF)and the visual function quality of life (VFQ) in primary chronic glaucoma patients. Methods: It is a retrospective case series study. One hundred and thirty-one patients, that is to say, two hundreds and sixty-two eyes, with primary chronic glaucoma satisfying the methodological criteria were recruited for this study, who were chosen from Beijing Tongren Hospital, Capital Medical University from March 2010 to August 2010. The Humphrey Field Analyzer Model II 750i (Humphrey Instruments, Zeiss Company) was used to perform an Esterman binocular visual field test (EBVFT) and bilateral monocular full-threshold central visual field testing using the 24-2 SITA Standard program. Visual acuities were examined by logarithm of the minimum angle of resolution (logMAR) scale. Intraocular pressure and cup-disc ratio were also recorded. The history with glaucoma and anti-glaucoma drugs, and the state of the cornea and crystalline lens were also remarked. All interviews were administered face to face by the same experienced interviewer, by using the 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25). Agreement between the scores from these tests and the VFQ- 25 was evaluated. Results: A total of 131 patients were recruited. In the statistics of the quality of life, seven domain scores of the VFQ-25 (self-assessment vision, color vision, near action, distant action, social function, mental health and peripheral vision) were better than the others, which meant the ability of completing the seven domain was higher. Substantial agreement was found between the composite score of the VFQ-25 and the Esterman test (r=0.24998, P=0.004<0.05), strong negative correlation was found between the composite score of the VFQ-25 and the binocular visual acuity of daily life (r=−0.37778, P<0.0001), and positive correlation was found between the composite score of the VFQ-25 and the MD of the worse eye (r=0.22917, P=0.0187<0.05). Conclusion: In

关 键 词：原发性慢性青光眼 双眼视觉 生活质量 

分 类 号：R775.2[医药卫生—眼科]