趋化因子和小胶质细胞在阿尔茨海默病神经炎症中的作用研究进展  

Progress in research on the role of chemokines and microglia in the neuroinflammation of Alzheimer’s disease

作　　者：王佳[1] 张丽 隗和儒 翟悦怡 刘树锋[1] 张连峰 WANG Jia;ZHANG Li;WEI Heru;ZHAI Yueyi;LIU Shufeng;ZHANG Lianfeng(Hebei Key Lab of Laboratory Animal Science,Hebei Medical University,Shijiazhuang 050017,China;Key Laboratory of Human Disease Comparative Medicine,National Health and Family Planning Commission of P.R.C,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences&Comparative Medicine Center,Peking Union Medical College,Beijing 100021)

机构地区：[1]河北省实验动物重点实验室河北医科大学,石家庄050017 [2]中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,卫计委人类疾病比较医学重点实验室,北京100021

出　　处：《中国比较医学杂志》2021年第6期139-147,共9页Chinese Journal of Comparative Medicine

基　　金：河北省科技基础条件建设与科技资源共享专项(18964802D,20567610D);国家自然科学基金面上项目(31970508)。

摘　　要：阿尔茨海默病(Alzheimer disease,AD)是一种以痴呆为主要症状的慢性进行性神经退行性疾病,主要神经病理学特征包括老年斑、神经原纤维缠结、神经炎症和神经元丢失。AD中的β-淀粉样蛋白沉积和错误折叠的Tau蛋白诱导小胶质细胞的激活,引起细胞因子、趋化因子的分泌,共同形成神经炎症反应影响AD的发展。本文总结了小胶质细胞激活和趋化因子释放在AD神经炎症中发挥的作用,为AD的治疗提供新的思路。Alzheimer’s disease(AD)is a chronic progressive neurodegenerative disease characterized by dementia as the main symptom.The main neuropathologic features include senile plaques,neurofibrillary tangles,neuroinflammation,and neuron loss.Deposition of amyloidβ-protein and misfolded tau protein in patients with AD induces the activation of microglia;this leads to the secretion of cytokines and chemokines,which jointly induce a neuroinflammatory response and affect the progression of AD.This review briefly summarizes the role of microglial activation and chemokine release in the neuroinflammation of AD and provides new insight into the treatment of AD.

关 键 词：趋化因子 小胶质细胞 神经炎症 阿尔茨海默病 

分 类 号：R-33[医药卫生]