卵巢上皮癌患者化疗前后血浆视黄醇结合蛋白、鳞状细胞癌抗原水平的变化及其对预后的影响  

Changes of the Levels of Plasma Retinol Binding Protein and Squamous Cell Carcinoma Antigen in Patients with Epithelial Ovarian Cancer Before and After Chemotherapy and Their Influence on Prognosis

作　　者：魏侠 WEI Xia(Department of Medical Laboratory,Puyang Oilfield General Hospital,Puyang 457001,China)

机构地区：[1]濮阳市油田总医院医学检验科,河南濮阳457001

出　　处：《河南医学研究》2021年第16期3030-3033,共4页Henan Medical Research

摘　　要：目的分析接受培美曲塞联合卡铂(PC)方案化疗的卵巢上皮癌(EOC)患者血浆视黄醇结合蛋白(RBP)、鳞状细胞癌抗原(SCCA)水平的变化及其对预后的影响。方法选取2017年1月至2020年6月濮阳市油田总医院收治的100例EOC患者。患者均接受PC方案化疗。化疗4个周期后,评估患者短期预后情况,并将患者分为预后良好组和预后不良组。比较两组患者化疗前、化疗4个周期后血浆RBP、SCCA水平。分析血浆RBP、SCCA水平对接受PC方案化疗的EOC患者预后的影响。分析血浆RBP与SCCA的相关性。结果在100例接受PC方案化疗的EOC患者中,预后良好组患者占68.00%(68/100),预后不良组患者占32.00%(32/100)。化疗前,预后不良组血浆RBP、SCCA水平高于预后良好组(P<0.05);化疗4个周期后,两组血浆RBP、SCCA水平低于化疗前,预后不良组血浆RBP、SCCA水平高于预后良好组(P<0.05)。经logistic回归分析结果显示,血浆RBP、SCCA水平高表达可增加接受PC方案化疗的EOC患者短期预后不良的风险(OR>1,P<0.05)。Pearson相关性分析显示,EOC患者的血浆RBP与SCCA水平呈正相关(r>0,P<0.05)。结论血浆RBP、SCCA水平可影响接受PC方案化疗的EOC患者的预后。血浆RBP、SCCA水平越高,可能提示患者的短期预后越差。Objective To analyze the changes of the levels of plasma retinol binding protein(RBP)and squamous cell carcinoma antigen(SCCA)in patients with epithelial ovarian cancer(EOC)who received chemotherapy with pemetrexed combined with carboplatin(PC)regimen and their influence on prognosiss.Methods A total of 100 patients with EOC admitted to Puyang Oilfield General Hospital from January 2017 to June 2020 were selected.All patients received chemotherapy with PC regimen.After 4 cycles of chemotherapy,the short-term prognosis was evaluated,and the patients were divided into good prognosis group and poor prognosis group.The levels of RBP and SCCA in plasma before chemotherapy and after 4 cycles of chemotherapy were compared between the two groups.The influences of the levels of RBP and SCCA in plasma on the prognosis of patients with EOC who received chemotherapy with PC regimen were analyzed.The relationship between plasma RBP and SCCA was analyzed.Results Among 100 patients with EOC who received chemotherapy with PC regimen,the patients in good prognosis group accounted for 68.00%(68/100),and the patients in poor prognosis group accounted for 32.00%(32/100).Before chemotherapy,the levels of plasma RBP and SCCA in poor prognosis group were higher than those in good prognosis group(P<0.05).After 4 cycles of chemotherapy,the levels of plasma RBP and SCCA in the two groups were lower than those before chemotherapy,and the levels of plasma RBP and SCCA in poor prognosis group were higher than those in good prognosis group(P<0.05).Logistic regression analysis showed that high expression of plasma RBP and SCCA could increase the risk of poor short-term prognosis of the patients with EOC who received chemotherapy with PC regimen(OR>1,P<0.05).Pearson correlation analysis showed that there was a positive correlation between the levels of plasma RBP and SCCA in patients with EOC(r>0,P<0.05).Conclusion The levels of RBP and SCCA in plasma could affect the prognosis of patients with EOC who received chemotherapy with PC regimen.The

关 键 词：卵巢上皮癌 培美曲塞 卡铂 视黄醇结合蛋白 鳞状细胞癌抗原 

分 类 号：R737.31[医药卫生—肿瘤]