强迫症患者前瞻记忆缺损性质及内表型  

Study on prospective memory deficits of obsessive-compulsive disorder patients in the endophenotype framework

作　　者：韦臻[1,2] 余嘉盛 阮中强 阳琼 Wei Zhen;Yu Jiasheng;Ruan Zhongqiang;Yang Qiong(Shenzhen Maternity and Child Healthcare Hospital,Shenzhen 518028,China;School of psychology/Center for Studies of Psychological Application,South China Normal University,Guangzhou 510631,China;Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou 510370,China)

机构地区：[1]深圳市妇幼保健院,广东深圳518028 [2]华南师范大学心理学院/心理应用研究中心,广东广州510631 [3]广州医科大学附属脑科医院,广东广州510370

出　　处：《四川精神卫生》2021年第3期220-225,共6页Sichuan Mental Health

摘　　要：目的考察强迫症患者前瞻记忆功能缺损情况以及强迫症患者未患病一级亲属的前瞻记忆功能,验证前瞻记忆作为强迫症内表型的潜在可能。方法选择年龄、受教育程度、性别、智商、婚姻状况相匹配的健康对照组、强迫症患者和强迫症患者一级亲属各25例,进行多试次设计的标准化前瞻记忆任务,将被试的正确反应率作为前瞻记忆功能的指标。结果强迫症患者组在基于事件的前瞻记忆和基于时间的前瞻记忆任务中正确率均低于健康对照组,差异均有统计学意义[(0.74±0.24)vs.(0.88±0.13),d=-0.140,P=0.044;(0.77±0.21)vs.(0.93±0.10),d=-0.164,P=0.011],强迫症患者一级亲属组在基于事件的前瞻记忆任务中正确率低于健康对照组,差异有统计学意义[(0.73±0.20)vs.(0.88±0.13),d=-0.144,P=0.036]。结论强迫症患者前瞻记忆缺损较广泛,且前瞻记忆可能是强迫症的一种内表型。Objective To study the prospective memory deficits of obsessive-compulsive disorder patients and unaffected first-degree relatives of patients,so as to validate the possibility of prospective memory as an endophenotype of obsessive-compulsive disorder.Methods Healthy controls,obsessive-compulsive disorder patients and unaffected first-degree relatives of patients,each with 25 cases,matched for age,education,gender,IQ and marriage status were enrolled.The standardized prospective memory paradigm with a multi-trial design was conducted,and the accuracy was used as an indicator of prospective memory function.Results The accuracy of event-and time-based prospective memory tasks of obsessive-compulsive disorder patients was lower than that of healthy controls,with statistical differences[(0.74±0.24)vs.(0.88±0.13),d=-0.140,P=0.044;(0.77±0.21)vs.(0.93±0.10),d=-0.164,P=0.011].The accuracy of event-based prospective memory task of unaffected first-degree relatives was also lower than that of healthy controls,with statistical difference[(0.73±0.20)vs.(0.88±0.13),d=-0.144,P=0.036].Conclusion Obsessive-compulsive disorder patients has extensive prospective memory deficits,indicating that prospective memory may be an endophenotype of obsessive-compulsive disorder.

关 键 词：强迫症 前瞻记忆 内表型 

分 类 号：R749[医药卫生—神经病学与精神病学]