当归芍药散对妊娠期子宫肌瘤大小的影响及对不良产科并发症的预防效果  

Effect of Danggui Shaoyao San on the Size of Uterine Fibroids During Pregnancy and Its Preventive Effect on Adverse Obstetric Complications

作　　者：吕晓芳 翟小娅 谢津 张慧 LYU Xiao-fang;ZHAI Xiao-ya;XIE Jin;ZHANG Hui(Shijiazhuang Maternal and Child Health Hospital,Shijiazhuang Hebei 050000)

机构地区：[1]石家庄市妇幼保健院,河北石家庄050000

出　　处：《世界中西医结合杂志》2021年第6期1128-1131,1136,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省中医药管理局课题(2019471)。

摘　　要：目的分析当归芍药散对妊娠期子宫肌瘤大小的影响及对不良产科并发症的预防效果。方法选取2017年7月—2019年7月期间就诊于石家庄市妇幼保健院的156例妊娠期子宫肌瘤患者作为研究对象,按照随机数字表法将其随机分为对照组和治疗组,各78例。对照组予以常规治疗,治疗组在对照组的基础上,采用当归芍药散治疗,两组均治疗1个月。观察两组孕妇子宫肌瘤大小在妊娠期的变化和不良产科并发症发生情况,比较两组新生儿情况及治疗前后的血清孕酮、人附睾蛋白4、糖类抗原125表达水平。结果治疗组妊娠6~12周与28~32周的肌瘤直径变化差值为(0.48±0.25)cm,明显小于对照组的(1.24±0.48)cm,两组比较,差异有统计学意义(P<0.05);治疗组剖宫产率、早产率、产后出血发生率均明显低于对照组,两组比较,差异有统计学意义(P<0.05);治疗组新生儿低出生体重发生率明显低于对照组,两组比较,差异有统计学意义(P<0.05);治疗组治疗后血清孕酮、人附睾蛋白4、糖类抗原125表达水平均明显低于对照组,两组比较,差异均有统计学意义(P<0.05)。结论当归芍药散联合西医常规治疗能有效抑制妊娠期子宫肌瘤增大,减少不良产科并发症和新生儿低出生体重发生,可能与降低孕酮、人附睾蛋白4、糖类抗原125表达水平有关,值得进一步研究应用。Objective To analyze the effect of Danggui Shaoyao San on the size of uterine fibroids during pregnancy and the preventive effect on adverse obstetric complications.Methods A total of 156 pregnant women with uterine fibroids in pregnancy in Shijiazhuang Maternity and Child Health Hospital from July 2017 to July 2019 were selected as the research subjects,and they were randomly divided into a control group and a treatment group according to a random number table,with 78 cases in each group;The control group was given routine treatment,and the treatment group was treated with Danggui Shaoyao San on the basis of the control group.Both groups were treated for 1 month.Observe the changes in the size of uterine fibroids during pregnancy and the occurrence of adverse obstetric complications in the two groups of pregnant women,compare the conditions of the two groups of newborns and the expression levels of serum progesterone,human epididymal protein 4,and carbohydrate antigen 125 before and after treatment.Results The difference in the diameter of fibroids between 6-12 weeks and 28-32 weeks of pregnancy in the treatment group was(0.48±0.25)cm,which was significantly smaller than that of the control group(1.24±0.48)cm.The difference between the two groups was statistically significant(P<0.05);The cesarean section rate,premature birth rate,and incidence of postpartum hemorrhage in the treatment group were significantly lower than those in the control group,and the difference between the two groups was statistically significant(P<0.05);the incidence of low birth weight in the treatment group was significantly lower Compared with the control group,the difference between the two groups was statistically significant(P<0.05);the expression levels of serum progesterone,human epididymal protein 4,and carbohydrate antigen 125 after treatment in the treatment group were significantly lower than those in the control group.There were differences between the two groups Statistically significant(P<0.05).Conclusion anggui Shaoyao San

关 键 词：妊娠 子宫肌瘤 当归芍药散 不良产科并发症 

分 类 号：R737.33[医药卫生—肿瘤] R711.5[医药卫生—临床医学]