鼻腔NK/T细胞淋巴瘤放疗中组织补偿物引入方式的剂量学差异  

The dosimetric difference in the way issue compensators are introduced during radiotherapy for nasal NK/T cell lymphoma

作　　者：王晓明 凌池芳 宋燕薇 曹怡健 宋斌斌 Wang Xiaoming

机构地区：[1]浙江省嘉兴市第一医院,314001 [2]复旦大学附属肿瘤医院,200032

出　　处：《浙江临床医学》2021年第6期810-812,共3页Zhejiang Clinical Medical Journal

摘　　要：目的探讨鼻腔NK/T细胞淋巴瘤放疗中两种组织补偿物引入方式的剂量学差异。方法选取2017年1月至2020年5月嘉兴市第一医院收治的原发鼻腔NK/T细胞淋巴瘤患者27例,所有患者定位及验证均基于CT扫描,据此分为定位组和验证组定位组采用虚拟组织补偿物设计逆向调强计划,验证组使用真实补偿物获得治疗计划。比较定位组计划中使用虚拟组织补偿物与验证组添加真实组织补偿物的剂量学差异。结果两组计划靶区剂量学比较,D_(98%)、D_(2%)、V_(95%)、V_(100%)、V_(110%)、CI和HI差异均有统计学意义(P<0.05);验证组的靶区覆盖不能满足临床要求。两组计划OAR受量比较,两侧晶体Dnux差异有统计学意义(P<0.05),验证组部分患者晶体超量。结论鼻腔NK/T细胞淋巴瘤调强放疗中组织补偿物的引入方式不一致,可导致靶区欠量及危及器官受量的改变。Objective To explore the dosimetric difference of the two ways of introducing tissue compensators in the radiotherapy of nasal NK/T cell lymphoma.Methods Twenty-seven patients with primary nasal NK/T-cell lymphoma admitted to Jiaxing First Hospital from January 2017 to May 2020 were selected.All patients were localized and verified based on CT scans,and were divided into localization group and verification group.The positioning group used the virtual tissue compensation to design the reverse intensity modulation plan,and the verification group used the real compensation to obtain the treatment plan.Compare the dosimetric difference between using virtual tissue compensation in the positioning group plan and adding real tissue compensation in the verification group.Results Comparing the planned target area dosimetry between the two groups,the differences in D_(98%),D_(2%),V_(95%),V_(100%),V_(110%),Cl and HI were statistically significant(P<0.05);the target area coverage of the verification group could not meet the clinical requirements.Comparing the planned OAR dose between the two groups,the difference in D„ux between the two sides of the lens was statistically significant(P<0.05),and some patients in the verification group had an excessive amount of lens.Conclusion Intensity-modulated radiotherapy of nasal NK/T-cell lymphoma has inconsistent introduction of tissue compensators,which can lead to under-dose of the target area and changes in the amount of endangered organs.

关 键 词：鼻腔NK/T细胞淋巴瘤 放射治疗 组织补偿物 剂量学 

分 类 号：R73[医药卫生—肿瘤]