槐杞黄颗粒对肝癌患者血清MMP-7表达的影响及疗效观察  

作　　者：吴云辉 陆许贞 王柯尹 

机构地区：[1]浙江省嘉兴市第一医院,314000

出　　处：《浙江临床医学》2021年第6期862-864,共3页Zhejiang Clinical Medical Journal

基　　金：嘉兴市科技计划项目(2018AD32097);高兴市重点学科支撑学科(传染病学)(2019-zr-02)。

摘　　要：目的观察肝癌患者口服槐杞黄颗粒治疗后其血清中基质金属蛋白酶7(MMP-7)水平的变化。方法90例肝癌患者随机分为常规治疗组和观察组,每组各45例,另选取健康者45例作为正常对照组。常规治疗组和观察组患者均行TACE介入治疗,未行放化疗或其他介入治疗,观察组在常规治疗的基础上加用槐杞黄颗粒。比较肝癌两组治疗前后患者的血清MMP-7水平,并进行随访及生存分析。结果治疗前,常规治疗组和观察组的血清MMP-7水平分别为(12.072±4.151)ng/ml和(11.679±4.253)ng/ml,明显高于正常对照组(1.856±0.772)ng/ml,差异均有统计学意义(t=13.465、14.003,P<0.001)。治疗后,观察组的血清MMP-7水平下降为(9.461±3.907)ng/ml,与治疗前、常规治疗组比较,差异均有统计学意义(P<0.05)。经随访,观察组肝癌患者的中位生存时间为16个月,对照组肝癌患者的中位生存时间为11个月,两组比较差异有统计学意义(P<0.05)。观察组患者的第1、2年的生存率分别为64.44%和44.83%,与常规治疗组比较,差异有统计学意义(P<0.05)。结论槐杞黄颗粒可通过调节MMP-7的表达改善肝癌的预后,延长肝癌患者的生存时间。Objective To observe the changes in serum levels of matrix metaUoproteinase 7(MMP-7)in patients with liver cancer after oral treatment with Huaiqihuang Granules.Methods Ninety patients with liver cancer were randomly divided into a conventional treatment group and an observation group,with 45 cases in each group,another 45 healthy parients were selected as the normal control group.All patients underwent TACE interventional therapy,no radiotherapy,chemotherapy or other interventional therapy.The observation group received Huaiqihuang Granules on the basis of conventional treatment.The serum MMP-7 levels of patients with liver cancer before and after treatment were compared,and follow-up and survival analysis were performed.Results Before treatment,the serum MMP-7 levels of the conventional treatment group and the observation group were(12.072±4.151)ng/ml and(11.679±4.253)ng/ml,which were significantly higher than the normal control group(1.856±0.772)ng/ml,The differences were statistically significant(13.465,14.003,P<0.001).After treatment,the serum MMP-7 level in the observation group decreased to(9.461±3.907)ng/ml,which was significantly different from the pre-treatment and conventional treatment group(P<0.05).After follow-up,the median survival time of liver cancer parients in the observation group was 16 months,and the median survival time of liver cancer patients in the control group was 11 months.The difference between the two groups was statistically significant(P<0.05).The first and second year survival rates of the observation group were 64.44%and 44.83%,respectively.Compared with the conventional treatment group,the difference was statistically significant(P<0.05).Conclusion Hu«iiqihuang granules can improve the prognosis ofliver cancer and prolong the survival time ofliver cancer patients by regulating the expression of MMP-7.

关 键 词：槐杞黄颗粒 肝细胞癌 基质金属蛋白酶7 

分 类 号：R73[医药卫生—肿瘤]