原发性肝癌行超声引导下射频消融术后并发肝功能衰竭的影响因素  

Influencing factors of liver failure after ultrasound-guided radio frequency ablation in patients with primary liver cancer

作　　者：吴云[1] 赵强坤 方岩[1] 刘秋迪 Wu Yun;Zhao Qiangkun;Fang Yan;Liu Qiudi(Department of Ultrasound,Shangqiu Municipal Hospital,Shangqiu First People’s Hospital Branch,Shangqiu 476100,China)

机构地区：[1]河南省商丘市立医院商丘市第一人民医院分院超声科,476100

出　　处：《中国实用医刊》2021年第10期56-59,共4页Chinese Journal of Practical Medicine

摘　　要：目的:探讨原发性肝癌行超声引导下射频消融术(RFA)后并发肝功能衰竭的影响因素。方法:抽取商丘市立医院2018年1月至2019年12月收治的原发性肝癌行超声引导下RFA术后并发肝功能衰竭患者40例为发生组,并抽取同期医院40例原发性肝癌行超声引导下RFA术后未并发肝功能衰竭患者资料作为未发生组。全部患者临床资料、实验室检验资料均完整,设计基线资料填写表,详细填写两组患者的一般资料,经单因素及多因素分析全部可能因素,找出原发性肝癌患者超声引导下RFA后并发肝功能衰竭的影响因素。结果:发生与未发生组患者肝功能Child-Pugh分级、肿瘤长径、合并血管癌栓、血清白细胞介素-6(IL-6)水平比较,P<0.05;组间其他资料比较,P>0.05;经Logistic回归分析结果显示,高Child-Pugh分级、肿瘤长径≥3 cm、合并血管癌栓、IL-6水平过表达是原发性肝癌患者超声引导下RFA后并发肝功能衰竭的影响因素(OR>1,P<0.05)。结论:高Child-Pugh分级、肿瘤长径≥3 cm、合并血管癌栓、IL-6水平过表达可增加原发性肝癌患者超声引导下RFA术后并发肝功能衰竭的风险。Objective To investigate the influencing factors of liver failure in patients with primary liver cancer after ultrasound-guided radio frequency ablation(RFA).Methods Forty patients with liver failure after ultrasound-guided RFA for primary liver cancer in Shangqiu Municipal Hospital from January 2018 to December 2019 were selected as the occurrence group,another 40 patients with primary liver cancer who had not complicated liver failure after RFA were selected as the non occurrence group.All patients'data and laboratory test data were complete.The baseline data filling form was designed.The general data of the two groups were filled in in detail,all possible factors were analyzed by univariate and multivariate analysis to find out the influencing factors of liver failure in patients with primary liver cancer after ultrasound-guided RFA.Results The comparison of Child-Pugh classification of liver function,tumor length,combined with vascular tumor thrombus and serum interleukin-6(IL-6)levels were compared between the two groups,P<0.05;The comparison of other data was compared between the two groups,P>0.05;through Logistic regression analysis,the results showed that high Child-Pugh classification,tumor length≥3 cm,combined with vascular tumor thrombus and overexpression of IL-6 levels were the influencing factors of liver failure after ultrasound-guided RFA in patients with primary liver cancer(OR>1,P<0.05).Conclusions High Child-Pugh classification,tumor length≥3 cm,combined with vascular tumor thrombus and overexpression of IL-6 levels may increase the risk of liver failure after ultrasound-guided RFA.

关 键 词：肝癌 射频消融术 超声 肝功能衰竭 

分 类 号：R735.7[医药卫生—肿瘤] R575.3[医药卫生—临床医学]