诱导化疗对局部晚期鼻咽癌患者营养状况和生活质量的影响  

Effects of induction chemotherapy on nutritional status and quality of life in patients with locally advanced nasopharyngeal carcinoma

作　　者：王萌[1] 肖杰 夏芳[2] 刘敏[1] 刘红 谢雪忆 冯果[1] 潘曦[2] WANG Meng;XIAO Jie;XIA Fang;LIU Min;LIU Hong;XIE Xue-yi;FENG Guo;PAN Xi(Department of Nutrition,The Third Xiangya Hospital,Central South University,Changsha 410078,China;Department of Oncology,The Third Xiangya Hospital,Central South University,Changsha 410078,China)

机构地区：[1]中南大学湘雅三医院营养科,长沙410078 [2]中南大学湘雅三医院肿瘤科,长沙410078

出　　处：《中国肿瘤临床与康复》2021年第6期695-698,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨诱导化疗对局部晚期鼻咽癌患者营养状况和生活质量的影响。方法选取2018年6月至2019年10月间中南大学湘雅三医院收治的81例初治局部晚期鼻咽癌患者,均采用多西他赛+顺铂(TP方案)诱导化疗,同时进行个体化营养支持治疗。采用营养风险筛查量表2002(NRS 2002)、主观整体营养评估量表(PG-SGA)、体质量指数(BMI)、去脂体质量指数(FFMI)和骨骼肌质量指数(ASMI)对患者治疗前后营养状况进行评估,运用肿瘤患者生活质量核心量表(QLQC30)和头颈部肿瘤患者生活质量量表分析患者治疗前后的生活质量。结果化疗后,患者NRS2002和PG-SGA评分均降低,差异均有统计学意义(P<0.05),ASMI较化疗前升高,差异有统计学意义(P<0.05),BMI和FFMI较化疗前无差异,差异无统计学意义(P>0.05)。诱导化疗后,患者QLQ-C30总体健康状况领域、躯体功能、角色功能、认知功能、情感功能和社会功能领域评分均升高,睡眠障碍、疲劳、缺乏食欲和疼痛等QLQ-C30特异症状改善,差异均有统计学意义(均P<0.05)。同时,疼痛、病态感、社交障碍等症状评分均下降,营养补充和体重增加评分上升,差异均有统计学意义(P<0.05)。结论诱导化疗可改善局部晚期鼻咽癌患者的营养状况,提高生活质量。Objective To investigate the effects of induction chemotherapy on nutritional status and quality of life in patients with locally advanced nasopharyngeal carcinoma( NPC). Methods Eighty-one NPC patients admitted to The Third Xiangya Hospital were selected from June 2018 to October 2019. All the patients received induction chemotherapy with docetaxel plus cisplatin( TP regimen). Meanwhile,the were given individualized nutritional support. The nutritional status was evaluated using nutrition risk screening( NRS2002),scored patient-generated subjective global assessment( PG-SGA),body mass index( BMI),fat free mass index( FFMI) and appendicular skeletal muscle mass index( ASMI). European Organization for Research and Treatment( EORTC) core quality of life questionnaire( QLQ-C30) and head and neck cancer specific module( EORTC QLQ-H&N35) were used to assess quality of life before and after treatment. Results The NRS 2002 and PG-SGA scores decreased and ASMI score increased after chemotherapy compared with those before chemotherapy( all P<0.05). The scores of QLQ-C30 including the overall health status,physical function,cognitive function,emotional function and social function were increased and scores of QLQ-H&N35 including sleep disorder,fatigue and pain were relieved( all P<0.05). Moreover,the scores of QLQ-H&N35 including pain,morbidity and social contact were decreased and the scores of the nutritional supplement and weight gain increased significantly( all P<0.05). Conclusion Induction chemotherapy can improve the nutritional status and quality of life in patients with locally advanced nasopharyngeal carcinoma.

关 键 词：局部晚期鼻咽肿瘤 诱导化疗 营养状况 生活质量 

分 类 号：R739.6[医药卫生—肿瘤]