雌激素受体α蛋白与BRAF^(V600E)蛋白在甲状腺乳头状癌中的表达及其临床意义  

Expression of estrogen receptor alpha protein and BRAF^(V600E)protein in thyroid papillary carcinoma and its clinical significance

作　　者：刘世阳 赵璐 王琨[1] 田瑶 刘宸光 桂正威 张林[1] Liu Shiyang;Zhao Lu;Wang Kun;Tian Yao;Liu Chenguang;Gui Zhengwei;Zhang Lin(Department of Thyroid and Breast Surgery,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院甲乳外科,武汉430030

出　　处：《中华普通外科杂志》2021年第6期436-439,共4页Chinese Journal of General Surgery

摘　　要：目的分析雌激素受体α(EKa)蛋白和BRAF^(V600E)甶在甲状腺乳头状癌(PTC)中的表达及其与PTC临床病理因素之间的关系。方法采用免疫组化染色的方法检测ERα蛋白和BRAF^(V600E)在1105例PTC组织中的表达,分析ERα和BRAF^(V600E)表达与PTC临床病理因素的关系,以及ERα与BRAF^(V600E)蛋白表达之间的关系:结果ERα蛋白阳性表达与男性(χ^(2)=6.087,P=0.001)、年龄<45岁(χ^(2)=5.197,P=0.023)及多灶性肿瘤(χ^(2)=4.446,P=0.035)均有关;BRAF^(V600E)蛋白阳性表达与ERα蛋白阳性(χ^(2)=6.209,P=0.013)、非桥本甲状腺炎(χ^(2)=29.388,P<0.001)、无侧方淋巴结转移(χ^(2)=6.849,P=0.009)及多灶性肿瘤(χ^(2)=9.596,P=0.035)均有关。结论男性、年龄<45岁、多灶性肿瘤及BRAF^(V600E)蛋ERα阳性的PTC患者更容易出现ERα阳性表达;BRAF^(V600E)蛋白可能抑制桥本甲状腺炎、肿瘤生长及侧方淋巴结转移的发生,促进多灶性肿瘤的发生。Objective To investigate the expression of estrogen receptor alpha(ERα)protein and BRAF^(V600E)protein in thyroid papillary carcinoma(PTC)and their relationship with clinical factors of PTC.Methods The expression of ERαand BRAF^(V600E)protein in 1105 PTC patients was detected by immunohistochemistry.The relationship among ERα,BRAF^(V600E)protein and clinical factors were analyzed.Results Positive ERαprotein was correlated with maleness (χ^(2)=6.087,P=0.001),age<45 years old(χ^(2)=5.197,P=0.023)and multifocal tumors(χ^(2)=4.446,P=0.035).Positive BRAF^(V600E)protein was correlated with positive ERot protein(χ^(2)=6.209,P=0.013),Hashimoto thyroiditis(χ^(2)=29.388,P<0.001),no lateral lymph node metastasis(χ^(2)=6.849,P=0.009)and multifocal tumors(χ^(2)=9-596,P=0.035).Conclusions ERαexpression is more common in male patients,patients younger than 45 years of age,those with multifocal tumors and positive BRAF^(V600E)protein.BRAF^(V600E)protein may inhibit Hashimoto's thyroiditis,tumor growth and the occurrence of lateral lymph node metastasis,and promote the occurrence of multiple focal tumors.

关 键 词：甲状腺肿瘤 雌激素受体Α 癌 乳头状 

分 类 号：R73[医药卫生—肿瘤]