缺铁性贫血与热性惊厥的相关性  

Correlation between iron deficiency anemia and febrile convulsion

作　　者：周锐[1] 徐向平[1] 邢梦楠 张国利[1] 刘卓琼[1] 李通拉嘎 Zhou Rui;Xu Xiangping;Xing Mengnan;Zhang Guoli;Liu Zhuoqiong;Litonglaga(Department of Pediatrics,the First Affiliated Hospital of Harbin Medical University,Heilongjiang 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院儿内科,黑龙江150001

出　　处：《脑与神经疾病杂志》2021年第6期373-377,共5页Journal of Brain and Nervous Diseases

摘　　要：目的确定缺铁性贫血(IDA)对儿童热性惊厥(FS)的影响。方法收集哈尔滨医科大学附属第一医院儿内科从2018年1月-2019年1月住院治疗的患者,所有患儿的年龄区间均为6个月到60个月,平均年龄为24.81月龄,将其分为两组,病例组包含104例FS儿童,对照组包含138例,其中36例为惊厥,102例为发热。对所有入组患者进行血液化验,测量红细胞(RBC)计数以及血红蛋白(Hb),血细胞比容(Hct),铁蛋白,平均红细胞体积(MCV),平均红细胞血红蛋白(MCH)和平均红细胞血红蛋白浓度(MCHC)水平。使用SPSS16软件分析收集的数据。结果热性惊厥患儿中患儿IDA的比例为35.3%,惊厥组患儿IDA所占比例为67.2%,发热组占比为43.6%,三组间进行比较,P>0.05。病例组的Hb,Hct和RBC水平较高,但是MCV,MCH,MCHC水平低于对照组。与发热组相比,FS组的优势比(OR)为0.756[95%置信区间(CI)=0.35–1.67;P=0.473],而与惊厥相比,FS组为0.264(95%CI=0.084-0.825;P=0.023)。结论这项研究表明IDA可能对FS发作有防治作用。Objective To determine the effect of iron deficiency anemia(IDA)on febrile seizure(FS)in children.Methods Patients hospitalized from January 2018 to January 2019 in the Department of Pediatrics of the First Affiliated Hospital of Harbin Medical University were collected.All the patients were aged from 6 months to 60 months,with an average age of 24.81 months.They were divided into two groups:104 children with FS in the case group and 138 cases in the control group,including 36 cases of convulsion and 102 cases of fever.Blood tests were performed on all enrolled patients,and the levels of hemoglobin(HB),hematocrit(HCT),ferritin,mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH)and mean corpuscular hemoglobin concentration(MCHC)were measured.Spss16 software was used to analyze the collected data.Results The proportion of IDA in children with febrile convulsion was 35.3%,67.2%in convulsion group and 43.6%in fever group,compared among the three groups,P>0.05.The levels of Hb,HCT and RBC were higher in the case group,but the levels of MCV,MCH and MCHC were lower than those in the control group.Compared with the febrile group,the difference was statistically significant(P=0.023;P=0.023;P=0.023;P=0.023;P=0.023,P=0.05).Conclusion This study suggests that IDA may have a preventive and therapeutic effect on FS.

关 键 词：缺铁性贫血 热性惊厥 儿童 

分 类 号：R720.597[医药卫生—急诊医学] R725.5[医药卫生—儿科]