乳癌病人血清sB7-H3表达及其临床意义  

EXPRESSION OF SERUM SOLUBLE HUMAN B7 HOMOLOG 3 AND ITS CLINICAL VALUE IN BREAST CANCER PATIENTS

作　　者：于超 周小凤 吕志栋[1] 毛艳[1] 韩清昕 吴琍[1] YU Chao;ZHOU Xiaofeng;L Zhidong;MAO Yan;HAN Qingxin;WU Li(Breast Center,The Affiliated Hospital of Qingdao University,Qingdao 266100,China)

机构地区：[1]青岛大学附属医院乳腺中心,山东青岛266100

出　　处：《青岛大学学报（医学版）》2021年第3期361-364,共4页Journal of Qingdao University(Medical Sciences)

基　　金：国家自然科学基金项目(81302290);山东省高等学校科技计划项目(J17KB092);青岛市应用基础研究计划项目(19-6-2-54-cg)。

摘　　要：目的探讨乳癌病人血清可溶性人B7同源体3(sB7-H3)表达及其临床意义。方法采用ELISA法,检测106例乳癌病人(乳癌组)和43例健康体检者(健康组)血清中sB7-H3表达,并分析乳癌病人血清sB7-H3表达与病理参数的关系。结果乳癌组血清sB7-H3表达明显高于健康组,差异有显著意义(t=8.530,P<0.01);血清sB7-H3最佳诊断截断值为21.73μg/L。单因素分析显示,血清中sB7-H3表达与乳癌病人术后的病理分期(pTNM)、是否有淋巴结转移以及肿瘤浸润淋巴细胞表达高低有关(t=-2.219~2.067,P<0.05),而与肿瘤大小、组织学分级、分子分型等无关(P>0.05)。结论血清sB7-H3可能成为筛选乳癌的重要肿瘤标志物,高表达的血清sB7-H3可能与乳癌预后不良有关。Objective To investigate the expression of serum soluble human B7 homolog 3(sB7-H3)and its clinical va-lue in breast cancer patients.Methods ELISA was used to measure the expression of sB7-H3 in the serum of 106 breast cancer patients(breast cancer group)and 43 healthy subjects who underwent physical examination(healthy group),and the association between serum sB7-H3 expression and pathological parameters was analyzed for breast cancer patients.Results The breast can-cer group had significantly higher expression of serum sB7-H3 than the healthy group(t=8.530,P<0.01),and the optimal cut-off value for diagnosis was 21.73μg/L.The univariate analysis showed that the expression of sB7-H3 in serum was associated with postoperative pathological staging,presence or absence of lymph node metastasis,and expression of tumor-infiltrating lymphocytes(t=-2.219 to 2.067,P<0.05),while it was not associated with tumor size,histological grade,and molecular typing(P>0.05).Conclusion Serum sB7-H3 is expected to become an important tumor marker for breast cancer screening,and highly expressed serum sB7-H3 may be associated with the poor prognosis of breast cancer.

关 键 词：乳房肿瘤 sB7-H3 血清 诊断 病理学 临床 

分 类 号：R737.9[医药卫生—肿瘤]