The Expression and Significance of CyclinD2,MPGES-1,Bcl2 in Diffuse Large B-cell Lymphoma  

作　　者：Qiushuang Ma Peng Lin Bingjuan Zhou Yafei Zhao Ling Li Jinku Zhang Jirui Sun 

机构地区：[1]Department of Pathology,Baoding First Central Hospital,Baoding 071000,Hebei province,China [2]Department of Hematology,Baoding First Central Hospital,Baoding 071000,Hebei province,China [3]Department of Orthopedics,Baoding First Hospital of Traditional Chinese Medicine,Baoding 071000,Hebei province,China [4]Department of Dermatology,Baoding First Central Hospital,Baoding 071000,Hebei province,China

出　　处：《Proceedings of Anticancer Research》2021年第2期53-56,共4页抗癌研究

基　　金：Qiushuang Ma and Peng Lin both are the first authors and contributed equally to this work.*Jinku Zhang and Jirui Sun are the corresponding authors and contributed equally to this work。

摘　　要：Objective:To study the expression and significance of cell cycle proteins CyclinD2,mPGES-1,Bcl2 in diffuse large B-cell lymphoma.Methods:Choose lymphoma and sexually hyper-plastic lymphoid tissues as control.Immunohistoc-hemical methods were used to detect the expression of CyclinD2,mPGES-1,and Bcl2,and to compare the positive expression rates of CyclinD2,MPGES-1 and Bcl2 in diffuse large B-cell lymphoma and reactive proliferative lymphoid tissues to compare their diffusion formation.B-cell lymphoma was analyzed for its clinicopathological features.Results:The positive expression rate of CyclinD2,mPGES-1 and Bcl2 in diffuse large B-cell lymphoma is higher than that in reactive proliferative lymphoid tissue,and the difference between the two is statistically significant.There was no statistical difference in CyclinD2,mPGES-1 and Bcl2 in diffuse large B-cell lymphoma between patients according to the age,sex,location,tissue type and degree of differentiation.Conclusion:CyclinD2,mPGES-1 and Bcl2 are highly expressed in patients with diffuse large B-cell lymphoma,and can be used as reference indicators for evaluating the malignant degree and efficacy of dysplasia.

关 键 词：CYCLIND2 MPGES-1 BCL2 Diffuse large B-cell lymphoma CLINICOPATHOLOGY 

分 类 号：R73[医药卫生—肿瘤]