SMILE与FS-LASIK术后调制传递函数在不同空间频率的变化  

Comparison of modulation transfer function between the eyes after small-incision lenticule extraction and femtosecond laser-assisted laser in situ keratomileusis

作　　者：崔彤 王雁[1] 张琳[1] 程文博[1] 赵伟[1] Cui Tong;Wang Yan;Zhang Lin;Cheng Wenbo;Zhao Wei(Clinical College of Ophthalmology,Tianjin Medical University,Tianjin Eye Hospital,Tianjin Key Lab of Ophthalmology and Visual Science,Tianjin 300020,China)

机构地区：[1]天津医科大学眼科临床学院,天津市眼科医院,天津市眼科学与视觉科学重点实验室,300020

出　　处：《中华实验眼科杂志》2021年第6期515-521,共7页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金项目(81470658)。

摘　　要：目的探讨飞秒激光小切口角膜基质透镜取出术(SMILE)与飞秒激光辅助准分子激光角膜原位磨镶术(FS-LASIK)术后眼调制传递函数(MTF)的变化。方法采用队列研究设计。收集2015年12月至2016年6月于天津市眼科医院屈光手术中心行SMILE和FS-LASIK的近视患者102例102眼,根据手术方式不同将其分为SMILE组53例53眼和FS-LASIK组49例49眼。采用Pentacam角膜地形图仪和WaveScan像差仪分别在术前和术后1、3、6个月检测角膜形态特征和像差,应用MTF进行计算和分析。比较2个组不同空间频率下不同时间点MTF值变化和术后6个月2个组去除低阶像差后MTF值变化,以及术后6个月SMILE组去除垂直彗差、水平彗差、球差后MTF值的变化。结果SMILE组和FS-LASIK组术后1、3、6个月各空间频率的MTF值较术前均明显升高,差异均有统计学意义(均P<0.05)。SMILE组术后1、3、6个月各空间频率MTF值均高于FS-LASIK组。除55 c/d、60 c/d外,其余空间频率下2个组术后6个月MTF值比较差异均有统计学意义(均P<0.05)。术后6个月去除低阶像差后,各空间频率下SMILE组的MTF值均明显高于FS-LASIK组,差异均有统计学意义(均P<0.05)。术后6个月1 c/d空间频率下SMILE组去除球差、水平彗差后MTF值明显高于去除前MTF值,差异均有统计学意义(均P<0.01);1 c/d、3 c/d空间频率下去除垂直彗差后MTF值明显高于去除前MTF值,差异均有统计学意义(均P<0.05),其余空间频率去除单项高阶像差后与术后6个月MTF值比较差异均无统计学意义(均P>0.05)。结论SMILE和FS-LASIK术后眼MTF均较术前升高,且SMILE术后MTF值较FS-LASIK术后MTF值略高。Objective To investigate and compare the changes of modulation transfer function(MTF)after small-incision lenticule extraction(SMILE)and femtosecond laser-assisted laser in situ keratomileusis(FS-LASIK).Methods A cohort study was conducted.One hundred and two myopic patients(102 eyes)who underwent SMILE and FS-LASIK in Tianjin Eye Hospital from December 2015 to June 2016 were enrolled and divided into SMILE group with 53 eyes and FS-LASIK group with 49 eyes according to different surgical methods.The ocular aberrations and corneal morphology of all patients were measured by the Hartman-Shack wave-front analyzer and Pentacam topography before surgery and 1,3 and 6 months postoperatively.MTF of optic system was calculated and analyzed.The changes of MTF values were compared between the two groups at different time points under different spatial frequencies,after removal of low-order aberrations at postoperative 6 months,and after removal of vertical coma aberration,horizontal coma aberration and spherical aberration in the SMILE group at postoperative 6 months.The study protocol complied with the Declaration of Helsinki and was approved by an Ethics Committee of Tianjin Eye Hospital(No.TJYYLL-2014-17).Written informed consent was obtained from each patient before surgery.Results Compared with the preoperative MTF,there were significant increases in postoperative 1-,3-and 6-month MTF at all spatial frequencies in the SMILE group and FS-LASIK group(all at P<0.05).MTF values at all spatial frequencies in the SMILE group were significantly higher than those in the FS-LASIK group at 1,3,and 6 months after surgery(all at P<0.05),except at 55 c/d and 60 c/d at 6 months postoperatively.The postoperative 6-month MTF values at all spatial frequencies without low-order aberration were higher in the SMILE group than those in the FS-LASIK group,showing significant differences between the two groups(all at P<0.05).In the SMILE group,the postoperative 6-month MTF values at 1 c/d spatial frequency without the horizontal coma aberr

关 键 词：调制传递函数 飞秒激光小切口角膜基质透镜取出术 飞秒激光辅助准分子激光角膜原位磨镶术 光学质量 

分 类 号：R779.63[医药卫生—眼科]