化疗-放疗-巩固化疗的序贯治疗模式治疗晚期宫颈癌的疗效分析  

Analysis of the efficacy of sequential treatment of chemotherapy-radiotherapyconsolidation chemotherapy in the treatment of advanced cervical cancer

作　　者：董巧兰 赵会菊 陈淑敏 DONG Qiaolan;ZHAO Huiju;CHEN Shumin(Department of Obstetrics and Gynecology,Xinzheng People’s Hospital,Zhengzhou 451100,He’nan,China)

机构地区：[1]新郑市人民医院妇产科,郑州451100

出　　处：《癌症进展》2021年第11期1161-1163,1171,共4页Oncology Progress

摘　　要：目的探讨化疗-放疗-巩固化疗的序贯治疗模式治疗晚期宫颈癌的疗效。方法依据术前治疗方法将110例晚期宫颈癌患者分为观察组(n=61)和对照组(n=49),观察组患者术前接受化疗-放疗-巩固化疗的序贯治疗,对照组患者术前接受新辅助化疗。比较两组患者的近期疗效、肿瘤标志物水平、病理特征、不良反应发生情况等。结果观察组患者临床总有效率为95.08%,高于对照组患者的85.71%(P﹤0.05)。治疗后,两组患者癌胚抗原(CEA)、鳞状上皮细胞抗原(SCCA)和糖类抗原125(CA125)均低于本组治疗前(P﹤0.05),且观察组患者CEA、SCCA和CA125水平均明显低于对照组(P﹤0.05)。观察组患者的术中出血量、淋巴结转移率、脉管癌栓发生率、直肠炎和胃肠道反应发生率均低于对照组(P﹤0.05)。结论与新辅助化疗相比,化疗-放疗-巩固化疗序贯治疗晚期宫颈癌患者效果显著,可降低肿瘤标志物水平和不良反应发生率。Objective To explore the effect of chemotherapy-radiotherapy-consolidation chemotherapy in the treatment of advanced cervical cancer.Method According to the preoperative treatment method,110 patients with advanced cervical cancer were divided into observation group(n=61)and control group(n=49).Patients in the observation group received chemotherapy-radiotherapy-consolidation chemotherapy before the operation,while patients in the control group received neoadjuvant chemotherapy before surgery.The short-term efficacy,tumor marker levels,pathological characteristics,and adverse reactions of the two groups were compared.Result The total clinical effective rate in the observation group was 95.08%,which was higher than 85.71%in the control group(P<0.05).After treatment,the serum carbohydrate antigen 125(CA125),squamous cell carcinoma antigen(SCCA),and carcinoembryonic antigen(CEA)of the two groups of patients were lower than those before treatment(P<0.05),and the levels of CEA,SCCA,and CA125 of the observation group were lower than those of the control group(P<0.05).The intraoperative blood loss,lymph node metastasis rate,vascular tumor thrombus incidence,proctitis and gastrointestinal reactions of the observation group were significantly lower than those of the control group(P<0.05).Conclusion Compared with neoadjuvant chemotherapy,sequential chemotherapy-radiotherapy-consolidation chemotherapy is effective in the treatment of patients with advanced cervical cancer,which can reduce the level of tumor markers and the incidence of adverse reactions.

关 键 词：化疗-放疗-巩固化疗的序贯治疗 新辅助化疗 宫颈癌 肿瘤标志物 

分 类 号：R737.33[医药卫生—肿瘤]