Correlation between KCNQ1 gene polymorphism and type 2 diabetes mellitus in Huaihai region of China  

作　　者：Xing Gao Dongmei Lv Yan Wang Tao Wang Wei Li Yanbo Zhang Yaqin Wei Jiali Zhang Qian Lu Xiaoxing Yin 

机构地区：[1]Laboratory of New Drugs and Clinical Application,Xuzhou Medical College,Xuzhou 221000,China [2]Pharmacy Department,The affiliated Hospital of Xuzhou Medical College,Xuzhou 221000,China [3]Endocrinology Department,The affiliated Hospital of Xuzhou Medical College,Xuzhou 221000,China [4]School of Pharmacy,Xuzhou Medical College,Xuzhou 221000,China

出　　处：《Family Medicine and Community Health》2014年第1期15-19,共5页家庭医学与社区卫生（英文）

基　　金：Students Practice and Innovation Training Project of Jiangsu,China in 2011;Colleges’Distinctive Discipline Construction Funding Project of Jiangsu,China。

摘　　要：Objective:This article aims to discuss the distribution of KCNQ1 gene polymorphism in the Chinese Han population in the Huaihai region of China and the correlation between KCNQ1 gene polymorphism and incidence of type 2 diabetes(T2DM).Methods:From December 2010 to July 2011,200 T2DM inpatients and outpatients in the Endocrinology Department of the Affiliated Hospital of Xuzhou Medical College were selected as the case group and,200 healthy people identified by the health examination center in the same re-gion were selected as the control group.The polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)test was used to examine the gene polymorphism of the two groups.Results:(1)Analysis on the control group showed that at the KCNQ1 rC237892 locus,the genotype frequencies of CC,CT and TT were 36.0%(72/200),51.0%(102/200)and 13.0%(26/200)respectively,and the allelic frequencies of C and T were 61.5%(246/400)and 38.5%(154/400)respectively.Analysis on the case group showed the genotype frequencies of CC,CT and TT were 47.5%(95/200),44.0%(88/200)and 8.5%(17/200)respectively,and the allelic frequencies of C and T were 69.5%(278/400)and 30.5%(122/400)respectively.Comparison between the genotype distributions and allelic frequencies of the two tested groups at KCNQ1 rC237892 locus showed differences with statistical significance(P<0.05).(2)Comparison be-tween the genotype distributions and allelic C and A frequencies of the control group and the case group showed differences with no statistical significance(P>0.05).Conclusion:Polymorphism at KCNQ1 rs2237892 locus may be correlated to the incidence of T2DM in the Chinese Han population in Huaihai region of China;polymorphism at rsl51290 locus may be irrelevant to the incidence of T2DM in the Chinese Han population in Huaihai region of China.

关 键 词：Type 2 diabetes mellitus KCNQ1 Genotype distribution Allelic frequency Poly-morphism MONONUCLEOTIDE 

分 类 号：R58[医药卫生—内分泌]