治疗口腔黏膜下纤维性变常用中药和西药的研究进展  

Research progress in the treatment of oral submucous fibrosis with traditional Chinese medicine and Western medicine

作　　者：肖婷[1] 唐瞻贵[1] XIAO Ting;TANG Zhangui(Department of Oral and Maxillofacial Surgery,Xianya Stomatology Hospi-tal,Xiangya School of Stomatology,Central South University,Changsha 410078,China)

机构地区：[1]中南大学湘雅口腔医院·湘雅口腔医学院口腔颌面外科,湖南长沙410078

出　　处：《口腔疾病防治》2021年第11期771-775,共5页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金项目(81671003)。

摘　　要：口腔黏膜下纤维性变是一种慢性、隐匿性和进行性的潜在恶性疾病,严重影响了患者的口腔功能和生活质量。口腔烧灼感和张口受限是患者就诊的主要原因,目前口腔黏膜下纤维性变的主要治疗方法仍是药物治疗。本文就常见的中、西药物治疗口腔黏膜下纤维性变的作用机制、治疗效果及其特点作一综述,为临床治疗口腔黏膜下纤维性变提供思路和参考。文献复习结果表明,丹参、芦荟、蕃茄红素、姜黄素等中药和西药治疗口腔黏膜下纤维性变具有较好的疗效;此外,桃红四物汤联合西药的中西药结合的治疗方案疗效显著并减少了毒副反应;临床医生可结合患者主要症状和全身情况选择合适的药物。未来研究者可探讨更多中西药结合方案治疗口腔黏膜下纤维性变。Oral submucous fibrosis is a chronic,occult and progressive potentially malignant disease that seriously affects the oral function and quality of life of patients.The oral burning sensation and limitation of mouth opening are the main reasons for patients to see a doctor.At present,the main treatment for oral submucosal fibrosis is still drug therapy.To provide ideas and references for the clinical treatment of oral submucosal fibrosis,this article reviews the mechanism,therapeutic effect and characteristics of common Chinese and Western medicine in the treatment of oral submucosal fibrosis.The results of the literature review show that salvia miltiorrhiza,aloe,lycopene,curcumin and other traditional Chinese medicine and Western medicine are effective in the treatment of oral submucosal fibrosis;in addition,Taohong Siwu Decoction combined with Western medicine and other combinations of traditional Chinese and Western medicine are effective and reduce side effects,and clinicians can choose appropriate drugs according to the patient's main symptoms and general condition.In the future,researchers can study more combinations of traditional Chinese and Western medicine to treat oral submucosal fibrosis.

关 键 词：口腔黏膜下纤维性变 潜在恶性疾病 烧灼感 张口受限 治疗 中药 丹参 西药 曲安奈德 中西药结合 

分 类 号：R78[医药卫生—口腔医学]