雌激素对牙周膜细胞修复重建牙周组织调节机制的研究进展  

Research progress on the regulatory mechanism of estrogen in periodontal ligament cells repair and the reconstruction of periodontal tissue

作　　者：黎祺[1] 王贺 黄紫君 韩倩倩 LI Qi;WANG He;HUANG Zijun;HAN Qianqian(Stomatological College of Zhaoqing Medical College,National Application Technology Collaborative Innovation Center of Primary Medical Ser-vice,Zhaoqing 526020,China;Department of Endodontics Periodontal,Stomatological Hospital,Southern Medical University,Guangzhou 510280,China;Department of Periodontal,Stomatological Hospital,Southern Medical Uni-versity,Guangzhou 510280,China)

机构地区：[1]肇庆医学高等专科学校口腔医学院国家基层医疗服务应用技术协同创新中心,广东肇庆526020 [2]南方医科大学口腔医院牙体牙髓病科,广东广州510280 [3]南方医科大学口腔医院牙周病科,广东广州510280

出　　处：《口腔疾病防治》2021年第11期787-792,共6页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金项目(82000994);广东省医学科研基金项目(A2018066)。

摘　　要：牙周组织再生修复是牙周病治疗的热点和难点,而牙周膜细胞的增殖、分化、迁移、黏附及与其胞外基质蛋白之间互相调节的动态关系,是牙周组织形态改建、功能维持和组织修复的基础。本文对雌激素调控下牙周膜细胞修复重建牙周组织的机制作一综述,为外源性雌激素替代治疗牙周炎和促进牙周组织修复重建的后续研究提供依据。在一定浓度的雌激素调控下,牙周膜干细胞(periodontal ligament stem cells,PDLSCs)、骨髓间充质干细胞(bone mesenchymal stem cells,BMSCs)向牙周膜细胞的增殖、分化能力增强,同时PDLSCs、BMSCs、牙周膜成纤维细胞(human periodontal ligament fibroblasts,HPLFs)、成骨细胞、成牙骨质细胞合成并往胞外基质中分泌胶原蛋白I型(collagen I,COLI)、骨桥蛋白(osteopontin,OPN)、骨涎蛋白(bone sialoprotein,BSP)、骨钙蛋白(osteocalcin,OCN)增多,与胞外基质中的纤维粘连蛋白(fibronectin,FN)、牙骨质附着蛋白(cementum attachment protein,CAP)等互相链接、结合形成多种链合物并相互调节,促进牙周膜细胞生长、迁移、黏附和纤维化,使牙周膜胶原纤维骨架修复并与新生牙骨质和固有牙槽骨重新黏附。Periodontium regeneration and repair is a controversial and difficult point in the treatment of periodontosis.The proliferation,differentiation,migration and adhesion of periodontal ligament cells and the dynamic relationship between periodontal ligament cells and their extracellular matrix proteins are the basis of periodontium morphological reconstruction,functional maintenance and tissue repair.This article reviews the mechanism of estrogenregulated periodontal membrane fine repair and periodontal tissue reconstruction to provide the basis for followup research on the treatment of periodontitis and the promotion of periodontal tissue repair and reconstruction by exogenous estrogenmediated periodontal membranes.Under the regulation of certain concentrations of estrogen,the proliferation and differentiation ability of periodontal ligament stem cells(PDLSCs)and bone mesenchymal stem cells(BMSCs)to other periodontal ligament cells were enhanced.At the same time,PDLSCs,BMSCs,human periodontal ligament fibroblasts(HPLFSs),osteoblasts and cementoblasts synthesized and secreted collagen I(COLI),osteopontin(OPN),bone sialoprotein(BSP)and osteocalcin(OCN)into the extracellular matrix.They interact with fibronectin(FN)and cementum attachment protein(CAP)in the extracellular matrix to form a variety of chain complexes and regulate each other,thus promoting the growth,migration,adhesion and fibrosis of periodontal ligament cells,repairing the collagen fiber skeleton of the periodontal ligament and adhering the two ends to the new cementum and the inherent alveolar bone.

关 键 词：雌激素 牙周膜干细胞 牙周膜成纤维细胞 成牙骨质细胞 成骨细胞 破骨细胞 骨髓间充质干细胞 胶原蛋白Ⅰ型 骨桥蛋白 骨涎蛋白 骨钙蛋白 

分 类 号：R781.4[医药卫生—口腔医学]