Anatomical correlates of blepharospasm  

作　　者：Silvina G Horovitz Anastasia Ford Muslimah Ali Najee-ullah John L Ostuni Mark Hallett 

机构地区：[1]Human Motor Control Section,Medical Neurology Branch,National Institute of Neurological Disorders and Stroke,10 Center Drive,Bdg10/7D37,Bethesda,MD,USA [2]Brain Rehabilitation Research Center,Malcom Randall VA Medical Center,Gainesville,FL,USA [3]Department of Psychology,University of Florida,Gainesville,FL,USA [4]Office of the Clinical Director,National Institute of Neurological Disorders and Stroke,Bethesda,MD,USA.

出　　处：《Translational Neurodegeneration》2012年第1期92-98,共7页转化神经变性病（英文）

基　　金：This research was supported by the Intramural Research Program of the National Institute of Neurological Disorders and Stroke,National Institutes of Health.

摘　　要：Background:Focal dystonia is a neurological disorder characterized by unwanted muscle spasms.Blepharospasm is a focal dystonia producing an involuntary closure of the eyelid.Its etiology is unknown.Objective:To investigate if there are structural changes in the white and grey matter of blepharospasm patients,and if the changes are related to disease features.Methods:T1 and diffusion-weighted magnetic resonance imaging scans were collected from 14 female blepharospasm patients and 14 healthy matched controls.Grey matter volumes,fractional anisotropy(FA),and mean diffusivity maps were compared between the groups.Based on grey matter differences within the facial portion of the primary motor cortex,the corticobulbar tract was traced and compared between groups.Results:Changes in grey matter in patients included the facial portion of the sensorimotor area and anterior cingulate gyrus.These changes did not correlate with disease duration.Corticobulbar tract volume and peak tract connectivity were decreased in patients compared with controls.There were no significant differences in FA or mean diffusivity between groups.Conclusions:Grey matter changes within the primary sensorimotor and the anterior cingulate cortices in blepharospasm patients may help explain involuntary eyelid closure and the abnormal sensations often reported in this condition.

关 键 词：BLEPHAROSPASM DYSTONIA Volumetric MRI Magnetic resonance imaging Diffusion weighted imaging 

分 类 号：R73[医药卫生—肿瘤]