沙参麦冬汤联合普拉洛芬治疗干眼症临床研究  

Clinical Study on Shashen Maidong Tang Combined with Pranoprofen for Xerophthalmia

作　　者：何雅微 吴佳琰 苏鹏[2] HE Yawei;WU Jiayan;SU Peng

机构地区：[1]宁波市镇海龙赛医院眼科,浙江宁波315200 [2]佛山市第二人民医院眼科,广东佛山528000

出　　处：《新中医》2021年第12期42-45,共4页New Chinese Medicine

摘　　要：目的:观察沙参麦冬汤联合普拉洛芬治疗干眼症的临床疗效。方法:将干眼症患者160例按随机数字表法分为观察组和对照组各80例。对照组给予普拉洛芬滴眼液治疗,观察组在对照组的基础上联合沙参麦冬汤治疗。治疗4周后,观察比较2组临床疗效,2组治疗前后视力水平、泪膜破裂时间(BUT)及泪液胸腺基质淋巴细胞生成素(TSLP)水平。结果:观察组总有效率为95.00%,对照组78.75%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组左、右眼视力(远近视)水平、BUT和泪液中TSLP水平比较,差异均无统计学意义(P>0.05);治疗后,2组左、右眼视力(远近视)水平、BUT、泪液中TSLP水平均较治疗前明显改善(P<0.05);且观察组左、右眼视力(远近视)水平、BUT、泪液中TSLP改善均优于对照组(P<0.05)。结论:沙参麦冬汤联合普拉洛芬滴眼液治疗干眼症疗效显著,可明显提高患者视力水平,延长BUT,降低TSLP水平。Objective:To observe the clinical effect of Shashen Maidong tang combined with pranoprofen for xerophthalmia.Methods:A total of 160 cases of patients with xerophthalmia were divided into the observation group and the control group according to the random number table method,80 cases in each group.The control group was treated with pranoprofen eye drops,and the observation group was additionally treated with Shashen Maidong tang based on the treatment of the control group.After four-week treatment,the breakup time of tear film(BUT)and the levels of visual acuity and thymic stromal lymphopoietin(TSLP)before and after treatment as well as the clinical effect in the two groups were observed and compared.Results:The total effective rate was 95.00%in the observation group and 78.75%in the control group,the difference being significant(P<0.05).Before treatment,there were no significant difference being found in the comparison of visual acuity(hyperopia and myopia)levels,BUT and TSLP levels in tears between the two groups(P>0.05).After treatment,the visual acuity(hyperopia and myopia)levels,BUT and TSLP levels in tears in the two groups were significantly improved when compared with those before treatment(P<0.05);the above indexes in the observation group were significantly better than those in the control group(P<0.05).Conclusion:The therapy of Shashen Maidong tang combined with pranoprofen eye drops has significant curative effect in treating xerophthalmia,which can significantly improve the visual acuity,prolong BUT,and reduce TSLP levels.

关 键 词：干眼症 沙参麦冬汤 普拉洛芬滴眼液 视力 泪膜破裂时间 胸腺基质淋巴细胞生成素 

分 类 号：R777.21[医药卫生—眼科]