LYVE-1 is'on stage'now:an emerging player in dendritic cell docking to lymphatic endothelial cells  

作　　者：Elena Rinaldi Fulvio Baggi 

机构地区：[1]Neurology IV-Neuroimmunology and Neuromuscular Diseases Unit,Neurological Institute‘Carlo Besta’,Milan,Italy

出　　处：《Cellular & Molecular Immunology》2018年第7期663-665,共3页中国免疫学杂志（英文版）

基　　金：The work is supported by the Italian Ministry of Health(WFR PE-2011-02346818).

摘　　要：The lymphatic system consists of a network of lymph capillaries and vessels deputed to drain the interstitial fluid(containing floating macromolecules,such as nutrients,cellular debris and tissue-infiltrating pathogens)and to transport tissue-patrolling lymphocytes and dendritic cells(DCs)to draining lymph nodes(drLNs).1 Knowledge of the mechanisms associated with cellular transmigration into the lymphatic system could offer the opportunity to manipulate the immune response in a wide range of diseases,such as autoimmune diseases and cancer.2,3 In this research highlight,we discuss a recent study that sheds light on our understanding of the molecules involved in DCs docking to lymphatic endothelial cells,a critical step prior to their subsequent endothelial transmigration into lymphatic vessels.DC docking occurs through the interaction between hyaluronan(hyaluronic acid,HA)molecules on the plasma membrane and lymphatic-vessel endothelial protein(LYVE-1).

关 键 词：LYMPHATIC DRAIN FLOATING 

分 类 号：R73[医药卫生—肿瘤]