Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films  

作　　者：Xiao Liu Jian-Wei Guo Ya-Dong Liu Ming Liu Hui Liu Miao-Miao Han Sheng-Xiang Ji 

机构地区：[1]Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [2]School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China

出　　处：《Chinese Journal of Polymer Science》2021年第8期1020-1028,I0007,共10页高分子科学（英文版）

基　　金：the National Natural Science Foundation of China(Nos.51773201 and 51973212);the Bureau of Science and Technology of Changchun(No.19SS005);the Department of Science and Technology of Jilin Province(No.20200301017RQ);the Joint Program of CAS-Jilin Province(No.2019SYHZ0002).

摘　　要：Medical devices-related infections pose a great threat to patients and cause an increased morbidity and mortality. Herein, we prepare an antibacterial composite(TPU-x) through blending medical grade thermoplastic polyurethane(TPU) and the complex(PL-DOSS) of ε-polylysine(ε-PL) and docusate sodium(DOSS). >99% reduction of colony forming unit(CFU) can be obtained in TPU-x composite films even at relatively low content of PL-DOSS, e.g. 0.13% for Methicillin resistant S. aureus(MRSA) and 0.5% for E. coli. The excellent antibacterial activity is mainly attributed to the formation of PL-DOSS nanoparticles that are uniformly dispersed in the TPU matrix with a size of ~100 nm. TPU-x composite films exhibit long-term stability in saline and good biocompatibility, and retain mechanical properties of TPU.

关 键 词：Nosocomial infections Antibacterial composite Solution blending Thermoplastic polyurethane POLYLYSINE 

分 类 号：TQ317[化学工程—高聚物工业] TB383.2[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]