阿尔茨海默病早期诊断的脑脊液和血液生物标志物研究  

Study on Cerebrospinal Fluid and Blood Biomarkers for Early Diagnosis of Alzheimer's Disease

作　　者：韦春英[1] 莫颖敏[1] WEI Chun-ying;MO Ying-min(Department of Geriatric Neurology,the People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,Guangxi,China)

机构地区：[1]广西壮族自治区人民医院老年神经内科,广西南宁530021

出　　处：《医学信息》2021年第14期25-27,共3页Journal of Medical Information

基　　金：广西壮族自治区卫生健康委员员会自筹课题(编号:Z20200425)。

摘　　要：阿尔茨海默病是老年期最常见的痴呆,发病率逐年增加,但其致病机制复杂,缺乏特异性治疗措施,因此早期诊断对于改善预后具有重要意义。目前,基于脑脊液及血液的生物标志物检测已经成为阿尔茨海默病早期诊断及治疗的重点之一。本文就阿尔茨海默病脑脊液及血液中的生物标志物Aβ相关的生物标志物、tau蛋白、脑脊液神经颗粒蛋白、血神经丝蛋白轻链、视锥蛋白1、炎症反应因子TREM2作一综述,以期为该病的临床早期诊断提供参考。Alzheimer's disease is the most common dementia in the elderly,and its incidence is increasing year by year.However,its pathogenic mechanism is complex and lacks specific treatment measures.Therefore,early diagnosis is of great significance for improving the prognosis.At present,the detection of biomarkers based on cerebrospinal fluid and blood has become one of the focuses of early diagnosis and treatment of Alzheimer's disease.This article reviews the biomarkers related to Alzheimer’s disease cerebrospinal fluid and blood biomarkers Aβ,tau protein,cerebrospinal fluid neurogranin,blood neurofilament light chain,trypsin 1,inflammatory response factor TREM2.It hopes to provide a reference for the early clinical diagnosis of the disease.

关 键 词：阿尔茨海默病 脑脊液 TAU蛋白 脑脊液神经颗粒蛋白 视锥蛋白1 

分 类 号：R742[医药卫生—神经病学与精神病学]