The dual roles of cytokines in Alzheimer’s disease:update on interleukins, TNF-α,TGF-β and IFN-γ  

作　　者：Cong Zheng Xin-Wen Zhou Jian-Zhi Wang 

机构地区：[1]Department of Pathophysiology,School of Basic Medicine and the Collaborative Innovation Center for Brain Science,Key Laboratory of Ministry of Education of China for Neurological Disorders,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [2]Co-innovation Center of Neuroregeneration,Nantong 226000,China

出　　处：《Translational Neurodegeneration》2016年第1期52-66,共15页转化神经变性病（英文）

基　　金：This work was supported in parts by grants from Natural Science Foundation of China(91132305,81261120570,81528007 and 81171195);The National Key Technology Research and Development Program of the Ministry of Science and Technology of China(2013DFG32670,2012BAI10B03).

摘　　要：Alzheimer’s disease(AD)is one of the most common neurodegenerative disorders in the elderly.Although the mechanisms underlying AD neurodegeneration are not fully understood,it is well recognized that inflammation plays a crucial role in the initiation and/or deterioration of AD neurodegeneration.Increasing evidence suggests that different cytokines,including interleukins,TNF-α,TGF-βand IFN-γ,are actively participated in AD pathogenesis and may serve as diagnostic or therapeutic targets for AD neurodegeneration.Here,we review the progress in understanding the important role that these cytokines or neuroinflammation has played in AD etiology and pathogenesis.

关 键 词：Alzheimer’s disease CYTOKINES INTERLEUKINS TNF-Α TGF-Β IFN-Γ 

分 类 号：R74[医药卫生—神经病学与精神病学]