The predictive value of SS-16 in clinically diagnosed Parkinson’s disease patients:comparison with ^(99m)Tc-TRODAT-1 SPECT scans  

作　　者：Wenyan Kang Fangyi Dong Dunhui Li Thomas J.Quinn Shengdi Chen Jun Liu 

机构地区：[1]Department of Neurology&Institute of Neurology,Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine,Shanghai,China [2]Department of Neurology,Ruijin Hospital North affiliated to Shanghai Jiaotong University School of Medicine,Shanghai,China [3]Department of Radiation Oncology,Beaumont Health System,Royal Oak,MI 48073,USA

出　　处：《Translational Neurodegeneration》2016年第1期126-130,共5页转化神经变性病（英文）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(81471287,81071024,81171202,81371407,30872729,30870879,81501097);the Shanghai Shuguang Program(11SG20);the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant(20152201);the Fifth National Undergraduate Student Innovating Program(2011015);The Scientific Research Program of Shanghai Health and Family Planning Commission(20144Y0220).

摘　　要：Background:Dopamine transporter based imaging has high diagnostic performance in distinguishing patients with Parkinson’s disease(PD)from patients with non-Parkinsonian syndromes.Our previous study indicated that the“Sniffin’Sticks”odor identification test(SS-16)acts as a valid instrument for olfactory assessment in Chinese PD patients.The aim of the study was to compare the efficacy of the two methods in diagnosing PD.Methods:Fifty-two PD patients were involved in this study and underwent single photon emission computed tomography(SPECT)imaging using the labeled dopamine transporter radiotracer ^(99)mTc-TRODAT-1 to assess nigrostriatal dopaminergic function.Olfactory function was assessed with the“Sniffin’Sticks”odor identification test(SS-16)in all patients who received DAT-SPECT scanning.Statistical analysis(SPSS version 21)was carried out to determine the diagnostic accuracy of SS-16 as well as its correlation with ^(99)mTc-TRODAT-1 SPECT,its positive predictive value(PPV),and negative predictive value(NPV).Results:We identified a negative correlation between SS-16 and DAT SPECT(Kappa=0.269,p=0.004).By using the ^(99)mTc-TRODAT-1 uptake results as the gold standard,the sensitivity and specificity of SS-16 was 56.8 and 37.5%,respectively.Furthermore,the negative and positive predictive values were calculated as 13.6 and 83.3%,respectively.Conclusions:SS-16 would not be used as a diagnostic tool for early stage PD patients.Negative results of SS-16 would not exclude the diagnosis of PD.Further tests are needed for validation.

关 键 词：Parkinson’s disease DAT-SPECT SS-16 

分 类 号：R74[医药卫生—神经病学与精神病学]