Treatment of leiomyomatosis peritonealis disseminata with goserelin acetate: A case report and review of the literature  

作　　者：Jia-Wen Yang Yu Hua Hua Xu Liu He Hai-Zhong Huo Chen-Fang Zhu 

机构地区：[1]Department of General Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Discipline Construction Research Center of China Hospital Development Institute,Shanghai Jiao Tong University,Shanghai 200011,China

出　　处：《World Journal of Clinical Cases》2021年第19期5217-5225,共9页世界临床病例杂志

摘　　要：BACKGROUND Leiomyomatosis peritonealis disseminata(LPD)is a rare condition characterized by multiple pelvic and abdominal nodules,which are composed of smoothmuscle cells.To date,no more than 200 cases have been reported.The diagnosis of LPD is difficult and there are no guidelines on the treatment of LPD.Currently,surgical excision is the mainstay.However,hormone blockade therapy can be an alternative choice.CASE SUMMARY A 33-year-old female patient with abdominal discomfort and palpable abdominal masses was admitted to our hospital.She had undergone four surgeries related to uterine leiomyoma in the past 8 years.Computed tomography revealed multiple nodules scattered within the abdominal wall and peritoneal cavity.Her symptoms and the result of the core-needle biopsy were consistent with LPD.The patient refused surgery and was then treated with tamoxifen,ulipristal acetate(a selective progesterone receptor modulator),and goserelin acetate(a gonadotropin-releasing hormone agonist).Both tamoxifen and ulipristal acetate were not effective in controlling the disease progression.However,the patient achieved an excellent response when goserelin acetate was attempted with relieved syndromes and obvious shrinkage of nodules.The largest nodule showed a 25%decrease in the sum of the longest diameters from pretreatment to posttreatment.Up to now,2 years have elapsed and the patient remains asymptomatic and there is no development of further nodules.CONCLUSION Goserelin acetate is effective for the management of LPD.The long-term use of goserelin acetate is thought to be safe and effective.Hormone blockade therapy can replace repeated surgical excision in recurrent patients.

关 键 词：Goserelin acetate Leiomyomatosis peritonealis disseminata Hormone blockade therapy Conservative treatment Disseminated peritoneal leiomyomatosis Case report 

分 类 号：R735.5[医药卫生—肿瘤]