中老年脑栓塞型脑梗死导致的AQP-4及TNF-α/IL-10失衡对患者神经元的损伤及脑梗死体积的影响  

Effect of TNF-α/IL-10 imbalance caused by cerebral embolism in middle-aged and elderly patients on neuronal damage and pain

作　　者：陈昭 魏志强[2] CHEN Zhao;WEI Zhiqiang(Department of Medical Records and Statistics,Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院病案统计科,天津300211 [2]天津医科大学第二医院神经内科,天津300211

出　　处：《中风与神经疾病杂志》2021年第6期509-512,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探究中老年脑栓塞型脑梗死导致的AQP-4及TNF-α/IL-10失衡对患者神经元的损伤及脑梗死体积的影响。方法选取在我院2018年4月-2020年8月进行治疗的中老年脑栓塞型脑梗死的患者及中老年脑栓塞非脑梗死患者作为研究对象,采集患者血液并通过ELISA法检测两组研究对象血清中AQP-4、TNF-α和IL-10,评估患者神经功能及脑梗死体积。结果中老年脑栓塞型脑梗死患者由于脑神经纤维细胞和胶质细胞及血管内皮细胞大量凋亡引起TNF-α及AQP-4异常分泌,引起TNF-α/IL-10的比值失衡和患者炎症反应和脑梗死体积增大,因此TNF-α/IL-10的比值失衡会在中老年脑栓塞型脑梗死患者血清中发生动态变化,可用于评估患者的病情程度,具有临床价值。结论中老年脑栓塞型脑梗死患者TNF-α及AQP-4异常分泌,TNF-α/IL-10的比值失衡;这些指标均可用于评估患者的病情程度,具有临床价值。Objective To explore the effect of TNF-α/IL-10 imbalance caused by cerebral embolism in middle-aged and elderly patients on neuronal damage and pain.Methods The middle-aged and elderly patients with cerebral embolism and non-cerebral infarction who were treated in our hospital from April 2018 to August 2020 were selected as research objects.The blood of these patients was collected and analyzed by ELISA method.TNF-αand IL-10 in the cerebrospinal fluid of the two groups of subjects were measured to evaluate the neurological function and pain degree of the patients.Results In middle-aged and elderly patients with cerebral embolism type cerebral infarction,the abnormal secretion of TNF-αwas caused by the apoptosis of neuronal cells.Glial cells and vascular endothelial cells contribute to the imbalance of TNF-α/IL-10 ratio and the patient’s inflammatory response and pain.Therefore,the imbalance of TNF-α/IL-10 ratio will dynamically change in the cerebrospinal fluid of middle-aged and elderly patients with cerebral embolism cerebral infarction,which can be used to evaluate the patient’s condition and has clinical value.Conclusion TNF-αin middle-aged and elderly patients with cerebral embolism cerebral infarction-αand AQP-4 abnormal secretion,TNF-α/the ratio of IL-10 was unbalanced;these indicators can be used to evaluate the degree of the patient’s condition,with clinical value.

关 键 词：脑栓塞 脑梗死 TNF-α IL-10 AQP-4 神经元损伤 

分 类 号：R743.3[医药卫生—神经病学与精神病学]