Mitochondria-localized β-actin is essential for priming innate antiviral immune signaling by regulating IRF3 protein stability  

作　　者：Xin Xie Martin Endara-Coll Raza Mahmood Robertas Jankauskas Tamara Gjorgjieva Piergiorgio Percipalle 

机构地区：[1]Science Division,Biology Program,New York University Abu Dhabi(NYUAD),P.O.Box 129188 Abu Dhabi,United Arab Emirates [2]Department of Molecular Biosciences,The Wenner-Gren Institute,Stockholm University,SE-10691,Stockholm,Sweden [3]New York University Center for Genomics and Systems Biology,NYU,New York,NY,USA

出　　处：《Cellular & Molecular Immunology》2019年第10期837-840,共4页中国免疫学杂志（英文版）

基　　金：This work was supported by grants provided by New York University Abu Dhabi as well as grants from the Swedish Research Council(Vetenskapsrådet)and the Swedish Cancer Society(Cancerfonden)to PP

摘　　要：Antiviral innate immunity acts as a defensive barrier to viral infection in both immune and nonimmune cells.The viral nucleic acids present in the cytoplasm after viral replication can activate sensors such as the RIG-I-like receptors RIG-I and MDA5 or the cytosolic DNA sensor cGAS to initiate signaling transduction.

关 键 词：immunity IMMUNE stability 

分 类 号：R51[医药卫生—内科学]