Glycomolecules in Echinococcus granulosus cyst fluid inhibit TLR4-mediated inflammatory responses via c-Raf  

作　　者：Jun Hou Linlin Li Dan Dong Lianghai Wang Xian Wang Kun Yang Xiaodan Xu Congzhe Chen Xiangwei Wu Xueling Chen 

机构地区：[1]Department of Immunology,Shihezi University School of Medicine,Shihezi,Xinjiang,China [2]Department of General Surgery,the First Affiliated Hospital,Shihezi University School of Medicine,Shihezi,Xinjiang,China

出　　处：《Cellular & Molecular Immunology》2020年第4期423-425,共3页中国免疫学杂志（英文版）

基　　金：supported by the National Natural Science Foundation of China(81760371,81760570,81602810,81703174);the XPCC Youth Science and Technology Innovation Leading Talent Program(2018CB017);Key Areas of Science and Technology Projects(2019AB031).

摘　　要：Cystic echinococcosis,which is caused by larval infection of Echinococcus granulosus(E.granulosus)sensu lato,is a widespread chronic cyst-forming helminthic disease that affects up to 3 million people.1 E.granulosus can actively divert the host immune response towards anergy and anti-inflammatory pathways.2 Previous studies have shown that E.granulosus can escape host immunosurveillance by modulating the maturation of dendritic cells(DCs).3,4 Nevertheless,how E.granulosus,an extracellular pathogen,modulates the inflammatory response in DCs remains poorly understood.In this study,we investigated the effects of E.granulosus cyst fluid(EgCF)on bone marrow-derived DCs(BMDCs)exposed to LPS,an inflammatory stimulus,and the mechanisms involved in the EgCF–DCs immune modulation.

关 键 词：FLUID INFLAMMATORY ECHINOCOCCUS 

分 类 号：R532.32[医药卫生—内科学]