柴胡疏肝散合香苏散治疗肝胃不和型胃脘痛的临床研究  

Clinical Study of Chaihu Shugan San and Xiangsu San in the Treatment of Epigastric Pain of Liver-Stomach Disharmony

作　　者：郑剑[1] 胡晓阳[1] 孙妲男[2] ZHENG Jian;HU Xiaoyang;SUN Danan(Heilongjiang University of Chinese Medicine,Harbin 150040,China;The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150001

出　　处：《中医药学报》2021年第7期79-84,共6页Acta Chinese Medicine and Pharmacology

基　　金：黑龙江省整理、传承老中医药专家学术思想课题(CZ14-01)。

摘　　要：目的:探讨柴胡疏肝散合香苏散对肝胃不和型胃脘痛的治疗效果。方法:选取2018年1月—2019年9月医院收治的肝胃不和型胃脘痛患者175例,以随机数表分为常规组(42例,常规西药治疗)、柴胡组(43例,常规西药治疗+柴胡疏肝散)、香苏组(44例,常规西药治疗+香苏散)、联合组(46例,常规西药治疗+柴胡疏肝散合香苏散)。对比4组患者治疗前后的中医积分情况,临床疗效,并对比4组患者治疗前后胃肠激素水平及治疗期间的不良反应发生情况。结果:4组治疗后主症积分、次症积分、总积分均降低(P<0.05),其中联合组积分均明显低于香苏组、柴胡组、常规组(P<0.05),香苏组、柴胡组积分均明显低于常规组(P<0.05)。4组临床疗效分布差异显著(P<0.05),联合组总有效率高于常规组(P<0.01)。4组治疗后胃动素(MTL)、生长抑素(SS)均提高(P<0.05),其中联合组MTL、SS明显高于香苏组、柴胡组、常规组(P<0.05),香苏组、柴胡组MTL、SS明显高于常规组(P<0.05);4组治疗后胃泌素(GAS)均降低(P<0.05),其中联合组GAS明显低于香苏组、柴胡组、常规组(P<0.05),香苏组、柴胡组GAS明显低于常规组(P<0.05)。4组患者治疗期间不良反应发生率相近(P>0.05)。结论:对肝胃不和型胃脘痛实施柴胡疏肝散合香苏散治疗可显著减轻患者病情,增强临床疗效,改善胃肠激素水平且安全性良好。Objective:To investigate the effect of Chaihu Shugan San and Xiangsu San in the treatment of epigastric pain of Liver-Stomach disharmony.Methods:A total of 175 patients with epigastric pain of Liver-Stomach disharmony were randomly divided into the conventional group(42 cases,conventional western medication),the Chaihu group(43 cases,conventional western medication combined with Chaihu Shugan San),the Xiangsu group(44 cases,conventional western medication combined with Xiangsu San)and the combined group(46 cases,conventional western medication combined with Chaihu Shugan San and Xiangsu San).The TCM scores and clinical efficacy,the gastrointestinal hormone levels before and after the treatment and the occurrence of adverse reactions during the treatment were compared in the four groups.Results:After the treatment,the scores of the primary symptoms,the secondary symptoms and the total scores were all decreased in the four groups(P<0.05);of which the scores in the combined group were significantly lower than those in the other three groups(P<0.05);the scores of the Xiangsu group and the Chaihu group were significantly lower than those of the conventional group(P<0.05).The distribution of clinical efficacy in the four groups was significantly different(P<0.05),and the total effective rate in the combined group was higher than that in the conventional group(P<0.01).After the treatment,the levels of motili(MTL)and somatostatin(SS)were all increased in the four groups(P<0.05);the levels of MTL and SS were significantly higher in the combined group than those in the other three groups(P<0.05),and the levels of MTL and SS were significantly higher in the Xiangsu group and the Chaihu group than those in the conventional group(P<0.05).The level of Gastrin(GAS)was decreased after the treatment in the four groups(P<0.05);the level of GAS in the combined group was significantly lower than that in the other three groups(P<0.05),and the level of GAS in the Xiangsu group and the Chaihu group was significantly lower than that in

关 键 词：柴胡疏肝散 香苏散 肝胃不和 胃脘痛 胃肠激素 效果 

分 类 号：R573[医药卫生—消化系统]