Reproducing indolent B-cell lymphoma transformation with T-cell immunosuppression in LMP1/CD40-expressing mice  

作　　者：Christelle Vincent-Fabert Alexis Saintamand Amandine David Mehdi Alizadeh François Boyer Nicolas Arnaud Ursula Zimber-Strobl Jean Feuillard Nathalie Faumont 

机构地区：[1]CNRS-UMR 7276 INSERM U1262 CRIBL,University of Limoges,and Hematology Laboratory of Dupuytren Hospital University Center(CHU)of Limoges,Limoges,France [2]INSERM U917,University of Rennes 1,Rennes,France [3]LNPRM,EFS Bretagne,Rennes,France [4]Research Unit Gene Vectors,Helmholtz Center Munich,German Research Center for Environmental Health GmbH,Munich,Germany

出　　处：《Cellular & Molecular Immunology》2019年第4期412-414,共3页中国免疫学杂志（英文版）

基　　金：The group of J Feuillard is supported by grants from the Ligue Nationale contre le Cancer(Equipe Labellisee Ligue),the Institut National contre le Cancer(INCa),the Comité Orientation Recherche Cancer(CORC),the Limousin Region and the Haute Vienne and Correze comitees of the Ligue Nationale contre le Cancer and by the Lyons Club of Correze;U Zimber-Strobl was supported by the German ResearchFoundation(SFB 1243,TP-A13).

摘　　要：Indolent B-cell lymphomas are a group of incurable cancers of the elderly that encompass various entities,such as chronic lymphocytic leukemia(CLL),follicular lymphoma(FL),and marginal zone lymphoma(MZL).All indolent lymphomas may evolve towards aggressive transformation with an increased proliferation index and decreased tumor doubling time.This transformation,which is called Richter’s syndrome in CLL,is associated with an aggressive clinical course and poor survival.At least in CLL,transformation of an indolent B-cell clone is molecularly different from that of de novo diffuse large B-cell lymphomas.1 Aging is known to be associated with immune decline,with increased inflammation,decreased immune surveillance and increased onset of malignancies among the consequences.2 Progression of indolent B-cell lymphomas is likely to be associated with escape from immune surveillance.

关 键 词：lymphoma RICHTER TRANSFORMATION 

分 类 号：R73[医药卫生—肿瘤]