Neuropilin-1: A feasible link between liver pathologies and COVID-19  

作　　者：Aitor Benedicto Iñigo García-Kamiruaga Beatriz Arteta 

机构地区：[1]Department of Cellular Biology and Histology,School of Medicine and Nursing,University of the Basque Country,Leioa 48940,Bizkaia,Spain [2]Department of Gastroenterology and Hepatology,San Eloy Hospital,Barakaldo 48902,Spain

出　　处：《World Journal of Gastroenterology》2021年第24期3516-3529,共14页世界胃肠病学杂志（英文版）

摘　　要：The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has a tremendous impact on the health of millions of people worldwide.Unfortunately,those suffering from previous pathological conditions are more vulnerable and tend to develop more severe disease upon infection with the new SARS-CoV-2.This coronavirus interacts with the angiotensin-converting enzyme 2 receptor to invade the cells.Recently,another receptor,neuropilin-1(NRP-1),has been reported to amplify the viral infection.Interestingly,NRP-1 is expressed in nonparenchymal liver cells and is related to and upregulated in a wide variety of liver-related pathologies.It has been observed that SARS-CoV-2 infection promotes liver injury through several pathways that may be influenced by the previous pathological status of the patient and liver expression of NRP-1.Moreover,coronavirus disease 2019 causes an inflammatory cascade called cytokine storm in patients with severe disease.This cytokine storm may influence liver sinusoidal-cell phenotype,facilitating viral invasion.In this review,the shreds of evidence linking NRP-1 with liver pathologies such as hepatocellular carcinoma,liver fibrosis,nonalcoholic fatty liver disease and inflammatory disorders are discussed in the context of SARS-CoV-2 infection.In addition,the involvement of the infection-related cytokine storm in NRP-1 overexpression and the subsequent increased risk of SARS-CoV-2 infection are also analyzed.This review aims to shed some light on the involvement of liver NRP-1 during SARSCoV-2 infection and emphasizes the possible involvement this receptor with the observed liver damage.

关 键 词：LIVER Liver sinusoidal endothelial cells Hepatic stellate cells SARS-CoV-2 COVID-19 PATHOLOGY 

分 类 号：R563.1[医药卫生—呼吸系统] R575[医药卫生—内科学]