血清中PKM2和TSGF水平与宫颈癌患者病情进展的相关性  

Study on the Correlation Between Serum PKM2 and TSGF and the Progression of Cervical Cancer

作　　者：孙红娜 王月荣 黄勇华[2] 陶伟华[2] 刘晓明 SUN Hongna;WANG Yuerong;HUANG Yonghua(The Third People's Hospital of Puyang,Puyang,457001)

机构地区：[1]河南省濮阳市第三人民医院,457001 [2]河南省濮阳市油田总医院,457001

出　　处：《实用癌症杂志》2021年第7期1072-1075,共4页The Practical Journal of Cancer

基　　金：河南省濮阳市科技攻关项目(编号:160229y04)。

摘　　要：目的探讨并分析血清中PKM2和TSGF水平与宫颈癌患者病情进展的相关性。方法选择110例宫颈癌及宫颈上皮瘤样病变患者为研究对象,分别为宫颈癌组(n=60)和癌前病变组(n=50),另选取同期进行健康体检的健康者50例为正常对照组,采用酶联免疫吸附实验(ELISA)检测3组研究对象血清中PKM2和TSGF的含量,并进一步分析PKM2、TSGF水平与宫颈癌患者临床病理特征以及病情进展的相关性。结果(1)与正常对照组相比,病变组和宫颈癌组患者血清中PKM2和TSGF含量均显著增加;与病变组相比,宫颈癌组患者血清中PKM2、TSGF含量也显著增加(P<0.05);(2)与肿瘤直径≤4 cm、Ⅰ~Ⅱ期、高分化程度、腺癌以及未发生淋巴结转移的患者相比,肿瘤直径>4 cm、Ⅲ~Ⅳ期、中低分化程度、鳞癌以及发生淋巴结转移的患者血清中PKM2和TSGF含量均显著升高(P<0.05);(3)宫颈癌血清PKM2和TSGF含量与患者病情进展具有显著正相关性(γ均>0,P均<0.05)。结论宫颈癌患者血清中PKM2和TSGF水平与宫颈癌患者临床特征以及病情进展密切相关,因此PKM2、TSGF的表达水平变化可作为女性宫颈癌筛查及诊断的评判指标。Objective To investigate and analyze the correlation between serum PKM2 and TSGF levels and the progression of cervical cancer patients.Methods 110 patients with cervical cancer and cervical epithelioma-like lesions were selected as the research objects,which were the cervical cancer group(n=60)and the precancerous lesion group(n=50).In addition,50 healthy people who had a physical examination during the same period were selected as the normal control group.Enzyme-linked immunosorbent assay(ELISA)was used to detect the levels of PKM2 and TSGF in the serum of the three groups of subjects,and further analyze the correlation between the levels of PKM2 and TSGF and the clinical pathological characteristics and disease progression of the patients.Results(1)Compared with the normal control group,the PKM2 and TSGF levels in the serum of patients in the lesion group and the cervical cancer group were significantly increased.Compared with the lesion group,the serum levels of PKM2 and TSGF levels in patients with cervical cancer also increased significantly(P<0.05);(2)Compared with patients with tumor diameter≤4cm,stage Ⅰ~Ⅱ,well differentiated degree,adenocarcinoma,and no lymph node metastasis,the serum PKM2 and TSGF levels in patients with tumor diameter>4 cm,stage Ⅲ~Ⅳ,moderately poorly differentiated degree,squamous cell carcinoma,and lymph node metastasis were significantly increased(P<0.05);(3)The serum PKM2 and TSGF levels in cervical cancer are significantly positively correlated with the patient’s disease progression(all γ>0,all P<0.05).Conclusion The levels of PKM2 and TSGF in the serum patients with cervical cancer are closely related to the clinical features and disease progression of patients with cervical cancer.Therefore,changes in the expression levels of PKM2 and TSGF can be used as indicators for screening and diagnosis of cervical cancer in women.

关 键 词：宫颈癌 丙酮酸激酶M2型 恶性肿瘤特异生长因子 癌变 病变 

分 类 号：R737.33[医药卫生—肿瘤]