VEGF和MMP-10在上皮性卵巢癌发生、发展中的作用及预后分析  

Role and Prognostic Analysis of VEGF and MMP-10 in the Development and Progression of Epithelial Ovarian Cancer

作　　者：董雪茹 王鹏远 DONG Xueru;WANG Pengyuan(Xuchang Central Hospital,Xuchang,461000)

机构地区：[1]河南科技大学附属许昌市中心医院,461000

出　　处：《实用癌症杂志》2021年第7期1080-1083,共4页The Practical Journal of Cancer

摘　　要：目的探讨血管内皮生长因子(VEGF)和基质金属蛋白酶10(MMP-10)在上皮性卵巢癌发生、发展中的作用及预后。方法选取80例上皮性卵巢癌患者,40例良性瘤组织患者以及30例交界瘤患者,采用免疫组化染色法检测VEGF和MMP-10表达。结果上皮性卵巢癌、良性瘤、交接瘤之间,VEGF和MMP-10表达有明显的差异性。VEGF、MMP-10表达与上皮性卵巢癌有无腹腔积液、病理分级、临床分期有明显相关性。MMP-10表达与上皮性卵巢癌预后无关。VEGF表达与上皮性卵巢癌预后有关。结论在上皮性卵巢癌的发生、发展中,肿瘤恶性侵袭与新生血管形成,有一定的相关性,VEGF表达与上皮性卵巢癌预后相关,可以作为预后判断的一个指标。Objective To explore the role and Prognostic analysis of VEGF and MMP-10 in the development and progression of epithelial ovarian cancer.Methods 80 patients with epithelial ovarian cancer,40 patients with benign tumor tissue,and 30 patients with borderline tumor were selected.The expressions of VEGF and mmp-10 were analyzed.Results There were significant differences in the expression of VEGF and MMP-10 among epithelial ovarian cancer,benign tumor and junction tumor.There were significant relation between the expressions of VEGF and MMP-10 and the presence or absence of ascites,pathological grade and clinical stage of epithelial ovarian cancer.Expression of MMP-10 was not associated with the prognosis of epithelial ovarian cancer.Expression of VEGF was associated with the prognosis of epithelial ovarian cancer.Conclusion In the occurrence and development of epithelial ovarian cancer,there is a certain correlation between tumor malignant invasion and neovascularization,expression of VEGF is associated with the prognosis of epithelial ovarian cancer,it can be used as an indicator of prognosis.

关 键 词：VEGF MMP-10 上皮性卵巢癌 预后 

分 类 号：R737.31[医药卫生—肿瘤]