盐酸吡柔比星、顺铂联合卡培他滨治疗进展期胃癌的效果分析  

Analysis of the Effect of Pirarubicin Hydrochloride,Cisplatin Combined with Capecitabine in the Treatment of Gastric Cancer in Progressive Stage

作　　者：张笑 卞卡 李鑫[1] ZHANG Xiao;BIAN Ka;LI Xin(Xuchang Central Hospital Affiliated to Henan University of Science and Technology,Xuchang,461000)

机构地区：[1]河南科技大学附属许昌市中心医院,461000

出　　处：《实用癌症杂志》2021年第7期1171-1174,共4页The Practical Journal of Cancer

摘　　要：目的探讨盐酸吡柔比星、顺铂联合卡培他滨治疗进展期胃癌的效果,指导进展期胃癌治疗方案的改进与优化。方法选择70例进展期胃癌患者作为研究对象,按照随机数字表法分为观察组(35例)和对照组(35例),观察组接受盐酸吡柔比星、顺铂联合卡培他滨治疗,对照组接受盐酸吡柔比星、顺铂联合5-氟尿嘧啶治疗,治疗以3周作为1个疗程,连续治疗2个疗程。于治疗前、治疗2个疗程测定2组肿瘤标志物[神经元特异性烯醇化酶(NSE)、糖类抗原(CA199)]水平并比较;于治疗前、治疗1个疗程、治疗2个疗程测定2组病灶直径并比较。治疗2个疗程结束后随访1年,比较2组生存率与生存时间;治疗期间记录2组不良反应发生情况,并比较差异。结果治疗2个疗程时,2组NSE、CA199均较治疗前降低,且观察组低于对照组(P<0.05)。治疗1个疗程、治疗2个疗程,2组病灶直径均较治疗前缩小,且观察组各时点病灶直径小于对照组(P<0.05)。随访1年,观察组生存率高于对照组,生存时间长于对照组(P<0.05)。2组不良反应比较,差异无统计学意义(P>0.05)。结论盐酸吡柔比星、顺铂联合卡培他滨治疗进展期胃癌可下调肿瘤标志物水平,缩小病灶,更有利于提高患者生存率、延长其生存时间,且不会增加不良反应,安全性好。Objective To investigate the effect of pirarubicin hydrochloride,cisplatin combined with capecitabine in the treatment of gastric cancer in progressive stage,and to guide the improvement and optimization of the treatment plan for gastric cancer in progressive stage.Methods 70 patients with gastric cancer in progressive stage were selected as the research subjects.According to the random number table method,they were divided into the observation group(35 cases)and the control group(35 cases).The observation group was received pirarubicin hydrochloride,cisplatin combined with capecitabine treatment,the control group was received pirarubicin hydrochloride,cisplatin combined with 5-fluorouracil treatment,3 weeks as a course of treatment and they were treated for 2 courses continuously.The levels of tumor markers[neuron-specific enolase(NSE)and carbohydrate antigen(CA199)]of the 2 groups were measured and compared before treatment and during 2 courses of treatment;the lesion diameters of the 2 groups were measured and compared before treatment,at 1 course of treatment,and 2 courses of treatment.Follow-up for 1 year after the end of 2 courses of treatment,compared the survival rate and survival time of the 2 groups;during treatment,the toxic and side effects were recorded,and the incidence rate was calculated and compared.Results After two courses of treatment,the NSE and CA199 of the 2 groups were lower than before treatment,and the observation group was lower than the control group(P<0.05);at 1 course of treatment and 2 courses of treatment,the diameter of the lesions in the 2 groups was smaller than before treatment,and the diameter of the lesions in the observation group was shorter than the control group at each time point(P<0.05);followed up for 1 year,the survival rate of the observation group was higher than that of the control group,and the survival time was longer than that of the control group(P<0.05);compared side effects between the 2 groups,the difference was not significant statistically(P>0.05).Conclusi

关 键 词：胃癌 进展期 盐酸吡柔比星 顺铂 卡培他滨 肿瘤标志物 病灶直径 生存状态 

分 类 号：R735.2[医药卫生—肿瘤]